A Protocol for Sedation Free MRI and PET Imaging in Adults with Autism Spectrum Disorder.

Journal Article (Journal Article)

Imaging technologies such as positron emission tomography (PET) and magnetic resonance imaging (MRI) present unparalleled opportunities to investigate the neural basis of autism spectrum disorder (ASD). However, challenges such as deficits in social interaction, anxiety around new experiences, impaired language abilities, and hypersensitivity to sensory stimuli make participating in neuroimaging studies challenging for individuals with ASD. In this commentary, we describe the existent training protocols for preparing individuals with ASD for PET/MRI scans and our own experience developing a training protocol to facilitate the inclusion of low-functioning adults with ASD in PET-MRI studies. We hope to raise awareness of the need for more information exchange between research groups about lessons learned in this context in order to include the entire disease spectrum in neuroimaging studies.

Full Text

Duke Authors

Cited Authors

  • Smith, CJ; Bhanot, A; Norman, E; Mullett, JE; Bilbo, SD; McDougle, CJ; Zürcher, NR; Hooker, JM

Published Date

  • July 2019

Published In

Volume / Issue

  • 49 / 7

Start / End Page

  • 3036 - 3044

PubMed ID

  • 31004246

Electronic International Standard Serial Number (EISSN)

  • 1573-3432

International Standard Serial Number (ISSN)

  • 0162-3257

Digital Object Identifier (DOI)

  • 10.1007/s10803-019-04010-3


  • eng