Improving recruitment and retention of adolescents and young adults with cancer in randomized controlled clinical trials.


Journal Article

Participation of adolescents and young adults (AYAs) with cancer in randomized clinical trials (RCTs) is necessary to advance treatments and psychosocial programs. Exploring AYAs experiences in an RCT will inform strategies to support recruitment and retention. A qualitative design was used to study the experiences of 13 AYAs in the Stories and Music for Adolescent and Young Adult Resilience during Transplant I (SMART I) trial. Key themes included: Weighing the Pros and Cons; Randomization Preferences; Completing Measures; and Worthwhile Experience. The experiences of AYAs during RCTs can bring insights that inform the design and management of AYA trials. Strategies include improving assent/consent processes, design of electronic interfaces and encouraging researcher flexibility.

Full Text

Duke Authors

Cited Authors

  • Docherty, SL; Crane, S; Haase, JE; Robb, SL

Published Date

  • April 11, 2019

Published In

PubMed ID

  • 30973826

Pubmed Central ID

  • 30973826

Electronic International Standard Serial Number (EISSN)

  • 2191-0278

International Standard Serial Number (ISSN)

  • 0334-0139

Digital Object Identifier (DOI)

  • 10.1515/ijamh-2018-0215


  • eng