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A Common Neuroendocrine Substrate for Diverse General Anesthetics and Sleep.

Publication ,  Journal Article
Jiang-Xie, L-F; Yin, L; Zhao, S; Prevosto, V; Han, B-X; Dzirasa, K; Wang, F
Published in: Neuron
June 5, 2019

How general anesthesia (GA) induces loss of consciousness remains unclear, and whether diverse anesthetic drugs and sleep share a common neural pathway is unknown. Previous studies have revealed that many GA drugs inhibit neural activity through targeting GABA receptors. Here, using Fos staining, ex vivo brain slice recording, and in vivo multi-channel electrophysiology, we discovered a core ensemble of hypothalamic neurons in and near the supraoptic nucleus, consisting primarily of neuroendocrine cells, which are persistently and commonly activated by multiple classes of GA drugs. Remarkably, chemogenetic or brief optogenetic activations of these anesthesia-activated neurons (AANs) strongly promote slow-wave sleep and potentiates GA, whereas conditional ablation or inhibition of AANs led to diminished slow-wave oscillation, significant loss of sleep, and shortened durations of GA. These findings identify a common neural substrate underlying diverse GA drugs and natural sleep and reveal a crucial role of the neuroendocrine system in regulating global brain states. VIDEO ABSTRACT.

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Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

June 5, 2019

Volume

102

Issue

5

Start / End Page

1053 / 1065.e4

Location

United States

Related Subject Headings

  • Supraoptic Nucleus
  • Sleep, Slow-Wave
  • Sleep
  • Proto-Oncogene Proteins c-fos
  • Propofol
  • Patch-Clamp Techniques
  • Optogenetics
  • Neurons
  • Neurology & Neurosurgery
  • Neuroendocrine Cells
 

Citation

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Jiang-Xie, L.-F., Yin, L., Zhao, S., Prevosto, V., Han, B.-X., Dzirasa, K., & Wang, F. (2019). A Common Neuroendocrine Substrate for Diverse General Anesthetics and Sleep. Neuron, 102(5), 1053-1065.e4. https://doi.org/10.1016/j.neuron.2019.03.033
Jiang-Xie, Li-Feng, Luping Yin, Shengli Zhao, Vincent Prevosto, Bao-Xia Han, Kafui Dzirasa, and Fan Wang. “A Common Neuroendocrine Substrate for Diverse General Anesthetics and Sleep.Neuron 102, no. 5 (June 5, 2019): 1053-1065.e4. https://doi.org/10.1016/j.neuron.2019.03.033.
Jiang-Xie L-F, Yin L, Zhao S, Prevosto V, Han B-X, Dzirasa K, et al. A Common Neuroendocrine Substrate for Diverse General Anesthetics and Sleep. Neuron. 2019 Jun 5;102(5):1053-1065.e4.
Jiang-Xie, Li-Feng, et al. “A Common Neuroendocrine Substrate for Diverse General Anesthetics and Sleep.Neuron, vol. 102, no. 5, June 2019, pp. 1053-1065.e4. Pubmed, doi:10.1016/j.neuron.2019.03.033.
Jiang-Xie L-F, Yin L, Zhao S, Prevosto V, Han B-X, Dzirasa K, Wang F. A Common Neuroendocrine Substrate for Diverse General Anesthetics and Sleep. Neuron. 2019 Jun 5;102(5):1053-1065.e4.
Journal cover image

Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

June 5, 2019

Volume

102

Issue

5

Start / End Page

1053 / 1065.e4

Location

United States

Related Subject Headings

  • Supraoptic Nucleus
  • Sleep, Slow-Wave
  • Sleep
  • Proto-Oncogene Proteins c-fos
  • Propofol
  • Patch-Clamp Techniques
  • Optogenetics
  • Neurons
  • Neurology & Neurosurgery
  • Neuroendocrine Cells