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Control of neural development and function by glial neuroligins.

Publication ,  Journal Article
Sakers, K; Eroglu, C
Published in: Curr Opin Neurobiol
August 2019

Neuroligins are a family of cell adhesion molecules, which are best known for their functions as postsynaptic components of the trans-synaptic neurexin-neuroligin complexes. Neuroligins are highly conserved across evolution with important roles in the formation, maturation and function of synaptic structures. Mutations in the genes that encode for neuroligins have been linked to a number of neurodevelopmental disorders such as autism and schizophrenia, which stem from synaptic pathologies. Owing to their essential functions in regulating synaptic connectivity and their link to synaptic dysfunction in disease, previous studies on neuroligins have focused on neurons. Yet a recent work reveals that neuroligins are also expressed in the central nervous system by glial cells, such as astrocytes and oligodendrocytes, and perform important roles in controlling synaptic connectivity in a non-cell autonomous manner. In this review, we will highlight these recent findings demonstrating the important roles of glial neuroligins in regulating the development and connectivity of healthy and diseased brains.

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Published In

Curr Opin Neurobiol

DOI

EISSN

1873-6882

Publication Date

August 2019

Volume

57

Start / End Page

163 / 170

Location

England

Related Subject Headings

  • Synapses
  • Neuroglia
  • Neurogenesis
  • Nerve Tissue Proteins
  • Cell Adhesion Molecules, Neuronal
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1109 Neurosciences
 

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Sakers, K., & Eroglu, C. (2019). Control of neural development and function by glial neuroligins. Curr Opin Neurobiol, 57, 163–170. https://doi.org/10.1016/j.conb.2019.03.007
Sakers, Kristina, and Cagla Eroglu. “Control of neural development and function by glial neuroligins.Curr Opin Neurobiol 57 (August 2019): 163–70. https://doi.org/10.1016/j.conb.2019.03.007.
Sakers K, Eroglu C. Control of neural development and function by glial neuroligins. Curr Opin Neurobiol. 2019 Aug;57:163–70.
Sakers, Kristina, and Cagla Eroglu. “Control of neural development and function by glial neuroligins.Curr Opin Neurobiol, vol. 57, Aug. 2019, pp. 163–70. Pubmed, doi:10.1016/j.conb.2019.03.007.
Sakers K, Eroglu C. Control of neural development and function by glial neuroligins. Curr Opin Neurobiol. 2019 Aug;57:163–170.
Journal cover image

Published In

Curr Opin Neurobiol

DOI

EISSN

1873-6882

Publication Date

August 2019

Volume

57

Start / End Page

163 / 170

Location

England

Related Subject Headings

  • Synapses
  • Neuroglia
  • Neurogenesis
  • Nerve Tissue Proteins
  • Cell Adhesion Molecules, Neuronal
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1109 Neurosciences