Management of recurrent Ewing sarcoma: challenges and approaches.

Journal Article (Journal Article;Review)

Although many patients with newly diagnosed Ewing sarcoma can become long-term survivors, relapse remains an important clinical problem for which there is no standard approach. Several prognostic factors have been identified, and these may help guide patient counseling and therapy decisions. A variety of chemotherapy regimens have produced responses in patients with recurrent Ewing sarcoma, but no comparative studies have been completed to show superiority of any one particular approach. In addition, the optimum length of therapy for salvage regimens and use of local control measures remains unknown. The likelihood of cure remains low and the gaps in our knowledge are great, and so enrollment on clinical trials should be strongly encouraged for these patients when feasible. Because Ewing sarcoma is relatively rare, some pediatric and adult oncologists may be less familiar with the management of relapsed patients. In this review, we address common questions facing the clinician and patient, and provide an update on new strategies for therapy.

Full Text

Duke Authors

Cited Authors

  • Van Mater, D; Wagner, L

Published Date

  • 2019

Published In

Volume / Issue

  • 12 /

Start / End Page

  • 2279 - 2288

PubMed ID

  • 30988632

Pubmed Central ID

  • PMC6441548

International Standard Serial Number (ISSN)

  • 1178-6930

Digital Object Identifier (DOI)

  • 10.2147/OTT.S170585


  • eng

Conference Location

  • New Zealand