Psychological intervention based on psychoneuroimmunology improves clinical evolution, quality of life, and immunity of children with leukemia: A preliminary study.

Journal Article (Journal Article)

We conducted a non-randomized, open-label clinical trial to assess whether a psychoneuroimmunology-based intervention enhanced immunity in children with acute lymphoblastic leukemia undergoing chemotherapy. In total, 16 children (44% female) received psychoneuroimmunology-based intervention, whereas 12 (50% female) received health psychoeducation (controls). The primary outcome was immunity markers, being clinical conditions the secondary outcome. Psychoneuroimmunology-based intervention increased immune markers (CD8+ T, B, and natural killer cells, serum immunoglobulin A, and immunoglobulin M) and quality of life, whereas it shortens the duration of fever and use of antipyretics, antibiotics, analgesics, and respiratory therapy. Immunity markers correlated with clinical conditions. Thus, psychoneuroimmunology-based intervention could reduce hospital cost and increase patient well-being.

Full Text

Duke Authors

Cited Authors

  • Chacin-Fernández, J; Chacin Fuenmayor, M; Piñerua-Shuhaibar, L; Suarez-Roca, H

Published Date

  • January 2019

Published In

Volume / Issue

  • 6 / 1

Start / End Page

  • 2055102919838902 -

PubMed ID

  • 30967959

Pubmed Central ID

  • PMC6444782

Electronic International Standard Serial Number (EISSN)

  • 2055-1029

International Standard Serial Number (ISSN)

  • 2055-1029

Digital Object Identifier (DOI)

  • 10.1177/2055102919838902


  • eng