A Workshop on Measuring the Progression of Atrophy Secondary to Stargardt Disease in the ProgStar Studies: Findings and Lessons Learned.

Published online

Journal Article

The Progression of Atrophy Secondary to Stargardt Disease (ProgStar) studies were designed to measure the progression of Stargardt disease through the use of fundus autofluorescence imaging, optical coherence tomography, and microperimetry. The overarching objectives of the studies were to document the natural course of Stargardt disease and identify the most appropriate clinical outcome measures for clinical trials assessing the efficacy and safety of upcoming treatments for Stargardt disease. A workshop organized by the Foundation Fighting Blindness Clinical Research Institute was held on June 11, 2018, in Baltimore, MD, USA. Invited speakers discussed spectral-domain optical coherence tomography, fundus autofluorescence, and microperimetry methods and findings in the ProgStar prospective study. The workshop concluded with a panel discussion of optimal endpoints for measuring treatment efficacy in Stargardt disease. We summarize the workshop presentations in light of the most current literature on Stargardt disease and discuss potential clinical outcome measures and endpoints for future treatment trials.

Full Text

Duke Authors

Cited Authors

  • Ervin, A-M; Strauss, RW; Ahmed, MI; Birch, D; Cheetham, J; Ferris, FL; Ip, MS; Jaffe, GJ; Maguire, MG; Schönbach, EM; Sadda, SR; West, SK; Scholl, HPN; ProgStar Study Group,

Published Date

  • April 2019

Published In

Volume / Issue

  • 8 / 2

Start / End Page

  • 16 -

PubMed ID

  • 31019847

Pubmed Central ID

  • 31019847

International Standard Serial Number (ISSN)

  • 2164-2591

Digital Object Identifier (DOI)

  • 10.1167/tvst.8.2.16

Language

  • eng

Conference Location

  • United States