Metabolic alterations and the potential for targeting metabolic pathways in the treatment of multiple myeloma.

Journal Article (Journal Article)

Metabolism is defined as the collection of complex biochemical processes that living cells use to generate energy and maintain their growth and survival. Metabolism encompasses the synthesis and breakdown of glucose, fatty acids, and amino acids; the generation of energy (ATP); and oxidative phosphorylation. In cancer cells, metabolism can be commandeered to promote tumor growth and cellular proliferation. These alterations in metabolism have emerged as an additional hallmark of various cancers. In this review we focus on metabolic alterations in multiple myeloma (MM) - a malignancy of plasma cells - including derangements in glycolysis, gluconeogenesis, the tricarboxylic acid cycle, oxidative phosphorylation, and fatty acid/amino acid synthesis and degradation. Particular focus is given to metabolic alterations that contribute to myeloma cell growth, proliferation and drug resistance. Finally, novel approaches that target metabolic pathways for the treatment of MM are discussed.

Full Text

Duke Authors

Cited Authors

  • Rizzieri, D; Paul, B; Kang, Y

Published Date

  • 2019

Published In

Volume / Issue

  • 5 /

PubMed ID

  • 31020046

Pubmed Central ID

  • PMC6476731

International Standard Serial Number (ISSN)

  • 2394-4722

Digital Object Identifier (DOI)

  • 10.20517/2394-4722.2019.05


  • eng

Conference Location

  • United States