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Transplant research in nonhuman primates to evaluate clinically relevant immune strategies in organ transplantation.

Publication ,  Journal Article
Fitch, Z; Schmitz, R; Kwun, J; Hering, B; Madsen, J; Knechtle, SJ
Published in: Transplant Rev (Orlando)
July 2019
Published version (DOI) Link to item

Research in transplant immunology using non-human primate (NHP) species to evaluate immunologic strategies to prevent rejection and prolong allograft survival has yielded results that have translated successfully into human organ transplant patient management. Other therapies have not proceeded to human translation due to failure in NHP testing, arguably sparing humans the futility and risk of such testing. The NHP transplant models are ethically necessary for drug development in this field and provide the closest analogue to human transplant patients available. The refinement of this resource with respect to colony MHC typing, reagent and assay development, and availability to the research community has greatly enhanced knowledge about transplant immunology and drug development.

Duke Scholars

Jean Kwun
Author Jean Kwun Surgery, Abdominal Transplant Surgery
Stuart Johnston Knechtle
Author Stuart Johnston Knechtle Surgery, Abdominal Transplant Surgery

Published In

Transplant Rev (Orlando)

DOI

10.1016/j.trre.2019.03.002

EISSN

1557-9816

Publication Date

July 2019

Volume

33

Issue

3

Start / End Page

115 / 129

Location

United States

Related Subject Headings

  • Transplantation Immunology
  • Surgery
  • Primates
  • Organ Transplantation
  • Models, Animal
  • Biomedical Research
  • Animals
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Fitch, Z., Schmitz, R., Kwun, J., Hering, B., Madsen, J., & Knechtle, S. J. (2019). Transplant research in nonhuman primates to evaluate clinically relevant immune strategies in organ transplantation. Transplant Rev (Orlando), 33(3), 115–129. https://doi.org/10.1016/j.trre.2019.03.002
Fitch, Zachary, Robin Schmitz, Jean Kwun, Bernhard Hering, Joren Madsen, and Stuart J. Knechtle. “Transplant research in nonhuman primates to evaluate clinically relevant immune strategies in organ transplantation.” Transplant Rev (Orlando) 33, no. 3 (July 2019): 115–29. https://doi.org/10.1016/j.trre.2019.03.002.
Fitch Z, Schmitz R, Kwun J, Hering B, Madsen J, Knechtle SJ. Transplant research in nonhuman primates to evaluate clinically relevant immune strategies in organ transplantation. Transplant Rev (Orlando). 2019 Jul;33(3):115–29.
Fitch, Zachary, et al. “Transplant research in nonhuman primates to evaluate clinically relevant immune strategies in organ transplantation.” Transplant Rev (Orlando), vol. 33, no. 3, July 2019, pp. 115–29. Pubmed, doi:10.1016/j.trre.2019.03.002.
Fitch Z, Schmitz R, Kwun J, Hering B, Madsen J, Knechtle SJ. Transplant research in nonhuman primates to evaluate clinically relevant immune strategies in organ transplantation. Transplant Rev (Orlando). 2019 Jul;33(3):115–129.
Journal cover image

Published In

Transplant Rev (Orlando)

DOI

10.1016/j.trre.2019.03.002

EISSN

1557-9816

Publication Date

July 2019

Volume

33

Issue

3

Start / End Page

115 / 129

Location

United States

Related Subject Headings

  • Transplantation Immunology
  • Surgery
  • Primates
  • Organ Transplantation
  • Models, Animal
  • Biomedical Research
  • Animals
  • 3202 Clinical sciences
  • 1103 Clinical Sciences