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Nephrogenic systemic fibrosis is associated with hypophosphataemia: a case-control study.

Publication ,  Journal Article
Bernstein, EJ; Isakova, T; Sullivan, ME; Chibnik, LB; Wolf, M; Kay, J
Published in: Rheumatology (Oxford)
September 2014

OBJECTIVE: Nephrogenic systemic fibrosis (NSF) is an iatrogenic fibrosing disorder that primarily affects individuals with chronic kidney disease (CKD) following exposure to gadolinium-based contrast agents (GBCAs). Derangements of calcium and phosphorus have been reported in patients with NSF. The aim of this study was to investigate potential factors in addition to GBCA exposure that may be involved in the pathogenesis of NSF. We hypothesized that patients with stage 5 CKD and NSF would manifest greater alterations in calcium, phosphorus and fibroblast growth factor 23 (FGF23) levels than those who do not have NSF. METHODS: Levels of phosphorus, calcium, FGF23 and 25-hydroxy-vitamin D were measured in 10 patients with stage 5 CKD and biopsy-proven NSF and in 19 patients with stage 5 CKD without NSF. Statistical analyses were performed using Fisher's exact test for categorical variables and the Kruskal-Wallis test for continuous variables. RESULTS: Patients with NSF had significantly lower phosphorus levels compared with controls (P = 0.01). There were no significant differences between NSF patients and controls in calcium, 25-hydroxy-vitamin D, intact parathyroid hormone or FGF23 levels. CONCLUSION: Differences in phosphorus metabolism may exist between patients with stage 5 CKD and NSF compared with patients with stage 5 CKD without NSF.

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Published In

Rheumatology (Oxford)

DOI

EISSN

1462-0332

Publication Date

September 2014

Volume

53

Issue

9

Start / End Page

1613 / 1617

Location

England

Related Subject Headings

  • Risk Factors
  • Renal Insufficiency, Chronic
  • Nephrogenic Fibrosing Dermopathy
  • Middle Aged
  • Male
  • Hypophosphatemia
  • Humans
  • Gadolinium
  • Fibroblast Growth Factor-23
  • Female
 

Citation

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Bernstein, E. J., Isakova, T., Sullivan, M. E., Chibnik, L. B., Wolf, M., & Kay, J. (2014). Nephrogenic systemic fibrosis is associated with hypophosphataemia: a case-control study. Rheumatology (Oxford), 53(9), 1613–1617. https://doi.org/10.1093/rheumatology/keu151
Bernstein, Elana J., Tamara Isakova, Mary E. Sullivan, Lori B. Chibnik, Myles Wolf, and Jonathan Kay. “Nephrogenic systemic fibrosis is associated with hypophosphataemia: a case-control study.Rheumatology (Oxford) 53, no. 9 (September 2014): 1613–17. https://doi.org/10.1093/rheumatology/keu151.
Bernstein EJ, Isakova T, Sullivan ME, Chibnik LB, Wolf M, Kay J. Nephrogenic systemic fibrosis is associated with hypophosphataemia: a case-control study. Rheumatology (Oxford). 2014 Sep;53(9):1613–7.
Bernstein, Elana J., et al. “Nephrogenic systemic fibrosis is associated with hypophosphataemia: a case-control study.Rheumatology (Oxford), vol. 53, no. 9, Sept. 2014, pp. 1613–17. Pubmed, doi:10.1093/rheumatology/keu151.
Bernstein EJ, Isakova T, Sullivan ME, Chibnik LB, Wolf M, Kay J. Nephrogenic systemic fibrosis is associated with hypophosphataemia: a case-control study. Rheumatology (Oxford). 2014 Sep;53(9):1613–1617.
Journal cover image

Published In

Rheumatology (Oxford)

DOI

EISSN

1462-0332

Publication Date

September 2014

Volume

53

Issue

9

Start / End Page

1613 / 1617

Location

England

Related Subject Headings

  • Risk Factors
  • Renal Insufficiency, Chronic
  • Nephrogenic Fibrosing Dermopathy
  • Middle Aged
  • Male
  • Hypophosphatemia
  • Humans
  • Gadolinium
  • Fibroblast Growth Factor-23
  • Female