αKlotho: FGF23 coreceptor and FGF23-regulating hormone.
Publication
, Journal Article
Jüppner, H; Wolf, M
Published in: J Clin Invest
December 2012
Low levels of phosphate can disrupt bone ossification and predispose to fractures. FGF23 is one of the major determinants of phosphate homeostasis, acting to increase urinary phosphate excretion. However, the regulation of FGF23 is incompletely understood. In this issue of the JCI, Smith et al. show that the cleaved form of αKlotho, the membrane-bound form of which is an FGF23 coreceptor, serves as a novel endocrine regulator of phosphate homeostasis, capable of inducing FGF23 production in osteocytes.
Duke Scholars
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Published In
J Clin Invest
DOI
EISSN
1558-8238
Publication Date
December 2012
Volume
122
Issue
12
Start / End Page
4336 / 4339
Location
United States
Related Subject Headings
- Receptors, Cell Surface
- Phosphates
- Klotho Proteins
- Immunology
- Glucuronidase
- Fibroblast Growth Factors
- Fibroblast Growth Factor-23
- Animals
- 42 Health sciences
- 32 Biomedical and clinical sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Jüppner, H., & Wolf, M. (2012). αKlotho: FGF23 coreceptor and FGF23-regulating hormone. J Clin Invest, 122(12), 4336–4339. https://doi.org/10.1172/JCI67055
Jüppner, Harald, and Myles Wolf. “αKlotho: FGF23 coreceptor and FGF23-regulating hormone.” J Clin Invest 122, no. 12 (December 2012): 4336–39. https://doi.org/10.1172/JCI67055.
Jüppner H, Wolf M. αKlotho: FGF23 coreceptor and FGF23-regulating hormone. J Clin Invest. 2012 Dec;122(12):4336–9.
Jüppner, Harald, and Myles Wolf. “αKlotho: FGF23 coreceptor and FGF23-regulating hormone.” J Clin Invest, vol. 122, no. 12, Dec. 2012, pp. 4336–39. Pubmed, doi:10.1172/JCI67055.
Jüppner H, Wolf M. αKlotho: FGF23 coreceptor and FGF23-regulating hormone. J Clin Invest. 2012 Dec;122(12):4336–4339.
Published In
J Clin Invest
DOI
EISSN
1558-8238
Publication Date
December 2012
Volume
122
Issue
12
Start / End Page
4336 / 4339
Location
United States
Related Subject Headings
- Receptors, Cell Surface
- Phosphates
- Klotho Proteins
- Immunology
- Glucuronidase
- Fibroblast Growth Factors
- Fibroblast Growth Factor-23
- Animals
- 42 Health sciences
- 32 Biomedical and clinical sciences