αKlotho: FGF23 coreceptor and FGF23-regulating hormone.
Journal Article (Journal Article)
Low levels of phosphate can disrupt bone ossification and predispose to fractures. FGF23 is one of the major determinants of phosphate homeostasis, acting to increase urinary phosphate excretion. However, the regulation of FGF23 is incompletely understood. In this issue of the JCI, Smith et al. show that the cleaved form of αKlotho, the membrane-bound form of which is an FGF23 coreceptor, serves as a novel endocrine regulator of phosphate homeostasis, capable of inducing FGF23 production in osteocytes.
Full Text
Duke Authors
Cited Authors
- Jüppner, H; Wolf, M
Published Date
- December 2012
Published In
Volume / Issue
- 122 / 12
Start / End Page
- 4336 - 4339
PubMed ID
- 23187136
Pubmed Central ID
- PMC3533569
Electronic International Standard Serial Number (EISSN)
- 1558-8238
Digital Object Identifier (DOI)
- 10.1172/JCI67055
Language
- eng
Conference Location
- United States