αKlotho: FGF23 coreceptor and FGF23-regulating hormone.

Journal Article (Journal Article)

Low levels of phosphate can disrupt bone ossification and predispose to fractures. FGF23 is one of the major determinants of phosphate homeostasis, acting to increase urinary phosphate excretion. However, the regulation of FGF23 is incompletely understood. In this issue of the JCI, Smith et al. show that the cleaved form of αKlotho, the membrane-bound form of which is an FGF23 coreceptor, serves as a novel endocrine regulator of phosphate homeostasis, capable of inducing FGF23 production in osteocytes.

Full Text

Duke Authors

Cited Authors

  • Jüppner, H; Wolf, M

Published Date

  • December 2012

Published In

Volume / Issue

  • 122 / 12

Start / End Page

  • 4336 - 4339

PubMed ID

  • 23187136

Pubmed Central ID

  • PMC3533569

Electronic International Standard Serial Number (EISSN)

  • 1558-8238

Digital Object Identifier (DOI)

  • 10.1172/JCI67055

Language

  • eng

Conference Location

  • United States