FGF23 or PTH: which comes first in CKD ?

Journal Article (Journal Article)

In the past 40 years, disordered mineral metabolism has been among the most intensely studied areas of nephrology. A June 2010 PubMed search for 'secondary hyperparathyroidism and kidney disease' yielded 5866 references. Among these are papers documenting the development and application of numerous therapeutic agents-including calcitriol, vitamin D analogs, phosphate binders, and cinacalcet-that remain in widespread use in the day-to-day management of dialysis patients worldwide. However, almost 6000 papers later, fundamental pathophysiological concepts remain unclear, particularly regarding the early pathogenesis of disordered mineral metabolism.

Full Text

Duke Authors

Cited Authors

  • Isakova, T; Wolf, MS

Published Date

  • November 2010

Published In

Volume / Issue

  • 78 / 10

Start / End Page

  • 947 - 949

PubMed ID

  • 21030968

Electronic International Standard Serial Number (EISSN)

  • 1523-1755

Digital Object Identifier (DOI)

  • 10.1038/ki.2010.281


  • eng

Conference Location

  • United States