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Prognostic value of radiographically defined extranodal extension in human papillomavirus-associated locally advanced oropharyngeal carcinoma.

Publication ,  Journal Article
Tian, S; Ferris, MJ; Switchenko, JM; Magliocca, KR; Cassidy, RJ; Jhaveri, J; Aiken, AH; Baugnon, KL; Hudgins, PA; Kendi, ATK; Patel, MR ...
Published in: Head Neck
September 2019

BACKGROUND: Pathologic extranodal extension (ENE) has traditionally guided the management of head and neck cancers. The prognostic value of radiographic ENE (rENE) in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (HPV + OPX) is uncertain. METHODS: Patients with HPV + OPX with adequate pretreatment radiographic nodal evaluation from a single institution were analyzed. rENE status was determined by neuroradiologists' at time of diagnosis. Distant metastasis-free survival (DMFS), overall survival (OS), and locoregional recurrence-free survival (LRFS) were estimated using Kaplan-Meier methods. Cox proportional hazards models were fit to assess the impact of rENE on survival endpoints. RESULTS: Hundred sixty-eight patients with OPX + squamous cell carcinomas diagnosed between April 2008 and December 2014 were included for analysis with median follow-up of 3.3 years. Eighty-eight percent of patients received concurrent chemoradiotherapy. rENE was not prognostic; its presence in patients with HPV + OPX did not significantly impact OS, LRFS, or DMFS. CONCLUSIONS: In patients with HPV + OPX, rENE was not significantly associated with OS, LRFS, or DMFS.

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Published In

Head Neck

DOI

EISSN

1097-0347

Publication Date

September 2019

Volume

41

Issue

9

Start / End Page

3056 / 3063

Location

United States

Related Subject Headings

  • Radiography
  • Proportional Hazards Models
  • Prognosis
  • Papillomavirus Infections
  • Otorhinolaryngology
  • Oropharyngeal Neoplasms
  • Neoplasm Staging
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Tian, S., Ferris, M. J., Switchenko, J. M., Magliocca, K. R., Cassidy, R. J., Jhaveri, J., … Beitler, J. J. (2019). Prognostic value of radiographically defined extranodal extension in human papillomavirus-associated locally advanced oropharyngeal carcinoma. Head Neck, 41(9), 3056–3063. https://doi.org/10.1002/hed.25791
Tian, Sibo, Matthew J. Ferris, Jeffrey M. Switchenko, Kelly R. Magliocca, Richard J. Cassidy, Jaymin Jhaveri, Ashley H. Aiken, et al. “Prognostic value of radiographically defined extranodal extension in human papillomavirus-associated locally advanced oropharyngeal carcinoma.Head Neck 41, no. 9 (September 2019): 3056–63. https://doi.org/10.1002/hed.25791.
Tian S, Ferris MJ, Switchenko JM, Magliocca KR, Cassidy RJ, Jhaveri J, et al. Prognostic value of radiographically defined extranodal extension in human papillomavirus-associated locally advanced oropharyngeal carcinoma. Head Neck. 2019 Sep;41(9):3056–63.
Tian, Sibo, et al. “Prognostic value of radiographically defined extranodal extension in human papillomavirus-associated locally advanced oropharyngeal carcinoma.Head Neck, vol. 41, no. 9, Sept. 2019, pp. 3056–63. Pubmed, doi:10.1002/hed.25791.
Tian S, Ferris MJ, Switchenko JM, Magliocca KR, Cassidy RJ, Jhaveri J, Aiken AH, Baugnon KL, Hudgins PA, Kendi ATK, Patel MR, Saba NF, Curran WJ, Beitler JJ. Prognostic value of radiographically defined extranodal extension in human papillomavirus-associated locally advanced oropharyngeal carcinoma. Head Neck. 2019 Sep;41(9):3056–3063.
Journal cover image

Published In

Head Neck

DOI

EISSN

1097-0347

Publication Date

September 2019

Volume

41

Issue

9

Start / End Page

3056 / 3063

Location

United States

Related Subject Headings

  • Radiography
  • Proportional Hazards Models
  • Prognosis
  • Papillomavirus Infections
  • Otorhinolaryngology
  • Oropharyngeal Neoplasms
  • Neoplasm Staging
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male