Prognostic value of radiographically defined extranodal extension in human papillomavirus-associated locally advanced oropharyngeal carcinoma.

Journal Article (Journal Article)

BACKGROUND: Pathologic extranodal extension (ENE) has traditionally guided the management of head and neck cancers. The prognostic value of radiographic ENE (rENE) in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (HPV + OPX) is uncertain. METHODS: Patients with HPV + OPX with adequate pretreatment radiographic nodal evaluation from a single institution were analyzed. rENE status was determined by neuroradiologists' at time of diagnosis. Distant metastasis-free survival (DMFS), overall survival (OS), and locoregional recurrence-free survival (LRFS) were estimated using Kaplan-Meier methods. Cox proportional hazards models were fit to assess the impact of rENE on survival endpoints. RESULTS: Hundred sixty-eight patients with OPX + squamous cell carcinomas diagnosed between April 2008 and December 2014 were included for analysis with median follow-up of 3.3 years. Eighty-eight percent of patients received concurrent chemoradiotherapy. rENE was not prognostic; its presence in patients with HPV + OPX did not significantly impact OS, LRFS, or DMFS. CONCLUSIONS: In patients with HPV + OPX, rENE was not significantly associated with OS, LRFS, or DMFS.

Full Text

Duke Authors

Cited Authors

  • Tian, S; Ferris, MJ; Switchenko, JM; Magliocca, KR; Cassidy, RJ; Jhaveri, J; Aiken, AH; Baugnon, KL; Hudgins, PA; Kendi, ATK; Patel, MR; Saba, NF; Curran, WJ; Beitler, JJ

Published Date

  • September 2019

Published In

Volume / Issue

  • 41 / 9

Start / End Page

  • 3056 - 3063

PubMed ID

  • 31046181

Pubmed Central ID

  • PMC6707079

Electronic International Standard Serial Number (EISSN)

  • 1097-0347

Digital Object Identifier (DOI)

  • 10.1002/hed.25791


  • eng

Conference Location

  • United States