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Sensitization to endothelial cell antigens: Unraveling the cause or effect paradox.

Publication ,  Journal Article
Jackson, AM; Delville, M; Lamarthée, B; Anglicheau, D
Published in: Hum Immunol
August 2019

Anti-endothelial cell antibodies (AECAs) have been correlated with increased acute and chronic rejection across all organ types and early graft dysfunction in kidney and heart transplantation. Nevertheless, the lack of appropriate tools and clear criteria for defining injurious versus non-injurious AECAs prohibits their routine inclusion in clinical risk assessments and diagnostic algorithms for antibody mediated injury. Clinical characterization of AECAs is complicated due to the wide range of polymorphic and non-polymorphic antigens expressed across different vascular tissues and the diverse array of specificities observed between individuals. This complexity is also reflected in the broad spectrum of reported injury phenotypes. AECAs detected at time of allograft dysfunction may represent biomarkers of past vascular injury or active contributors to a current rejection process. New tools within the fields of proteomics, genomics, bioinformatics, and imaging are currently being validated and hold great promise for unraveling the AECA paradox.

Duke Scholars

Published In

Hum Immunol

DOI

EISSN

1879-1166

Publication Date

August 2019

Volume

80

Issue

8

Start / End Page

614 / 620

Location

United States

Related Subject Headings

  • Organ Transplantation
  • Organ Specificity
  • Isoantigens
  • Immunology
  • Immunization
  • Humans
  • Graft Rejection
  • Exosomes
  • Endothelial Cells
  • Biomarkers
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Jackson, A. M., Delville, M., Lamarthée, B., & Anglicheau, D. (2019). Sensitization to endothelial cell antigens: Unraveling the cause or effect paradox. Hum Immunol, 80(8), 614–620. https://doi.org/10.1016/j.humimm.2019.04.014
Jackson, Annette M., Marianne Delville, Baptiste Lamarthée, and Dany Anglicheau. “Sensitization to endothelial cell antigens: Unraveling the cause or effect paradox.Hum Immunol 80, no. 8 (August 2019): 614–20. https://doi.org/10.1016/j.humimm.2019.04.014.
Jackson AM, Delville M, Lamarthée B, Anglicheau D. Sensitization to endothelial cell antigens: Unraveling the cause or effect paradox. Hum Immunol. 2019 Aug;80(8):614–20.
Jackson, Annette M., et al. “Sensitization to endothelial cell antigens: Unraveling the cause or effect paradox.Hum Immunol, vol. 80, no. 8, Aug. 2019, pp. 614–20. Pubmed, doi:10.1016/j.humimm.2019.04.014.
Jackson AM, Delville M, Lamarthée B, Anglicheau D. Sensitization to endothelial cell antigens: Unraveling the cause or effect paradox. Hum Immunol. 2019 Aug;80(8):614–620.
Journal cover image

Published In

Hum Immunol

DOI

EISSN

1879-1166

Publication Date

August 2019

Volume

80

Issue

8

Start / End Page

614 / 620

Location

United States

Related Subject Headings

  • Organ Transplantation
  • Organ Specificity
  • Isoantigens
  • Immunology
  • Immunization
  • Humans
  • Graft Rejection
  • Exosomes
  • Endothelial Cells
  • Biomarkers