A case report on metastatic ileal neuroendocrine neoplasm to the breast masquerading as primary breast cancer: A diagnostic challenge and management dilemma.


Journal Article

RATIONALE:Metastatic neuroendocrine neoplasms (NENs) to the breast are very rare entities comprising only 1% to 2% of all metastatic breast tumors. In this article, we describe a case of a neuroendocrine ileal neoplasm metastatic to breast and liver, with breast metastatic tumor to be the initial manifestation of the disease. PATIENT CONCERNS:We herein report a rare case of a female patient admitted to our department with a palpable painful mass on her left breast. DIAGNOSIS:The surgical and histological investigation revealed a metastatic neuroendocrine neoplasm to the breast originated from terminal ileum. INTERVENTIONS:A left lumpectomy, right hemicolectomy, cholecystectomy, left hepatectomy along with liver metastasectomies (V, VI, VIII) plus radiofrequency ablation of lesions to the right liver lobe plus standard lymphadenectomy was performed. OUTCOMES:Considering the advanced stage of the disease, the patient received an adjuvant therapy of somatostatin analog plus everolimus. Under the guidance of oncological consultation, patients follow-up with CT and MRI scan and clinical re-evaluations in the first 3 and 6 months, substantiates no evidence of recurrence and she presents herself asymptomatic. LESSONS:An appropriate level of suspicion and selective immunohistochemistry in these cases, particularly where no prior history of a known primary neuroendocrine neoplasm occurs, may help to diagnose a previously undetected neuroendocrine tumor elsewhere in the body and provide guidance for the appropriate treatment selection.

Full Text

Duke Authors

Cited Authors

  • Papalampros, A; Mpaili, E; Moris, D; Sarlanis, H; Tsoli, M; Felekouras, E; Trafalis, DT; Kontos, M

Published Date

  • April 2019

Published In

Volume / Issue

  • 98 / 16

Start / End Page

  • e14989 -

PubMed ID

  • 31008928

Pubmed Central ID

  • 31008928

Electronic International Standard Serial Number (EISSN)

  • 1536-5964

International Standard Serial Number (ISSN)

  • 0025-7974

Digital Object Identifier (DOI)

  • 10.1097/MD.0000000000014989


  • eng