Age-related delay in visual and auditory evoked responses is mediated by white- and grey-matter differences.

Journal Article (Journal Article)

Slowing is a common feature of ageing, yet a direct relationship between neural slowing and brain atrophy is yet to be established in healthy humans. We combine magnetoencephalographic (MEG) measures of neural processing speed with magnetic resonance imaging (MRI) measures of white and grey matter in a large population-derived cohort to investigate the relationship between age-related structural differences and visual evoked field (VEF) and auditory evoked field (AEF) delay across two different tasks. Here we use a novel technique to show that VEFs exhibit a constant delay, whereas AEFs exhibit delay that accumulates over time. White-matter (WM) microstructure in the optic radiation partially mediates visual delay, suggesting increased transmission time, whereas grey matter (GM) in auditory cortex partially mediates auditory delay, suggesting less efficient local processing. Our results demonstrate that age has dissociable effects on neural processing speed, and that these effects relate to different types of brain atrophy.

Full Text

Duke Authors

Cited Authors

  • Price, D; Tyler, LK; Neto Henriques, R; Campbell, KL; Williams, N; Treder, MS; Taylor, JR; Cam-CAN, ; Henson, RNA

Published Date

  • June 9, 2017

Published In

Volume / Issue

  • 8 /

Start / End Page

  • 15671 -

PubMed ID

  • 28598417

Pubmed Central ID

  • PMC5472747

Electronic International Standard Serial Number (EISSN)

  • 2041-1723

Digital Object Identifier (DOI)

  • 10.1038/ncomms15671


  • eng

Conference Location

  • England