The role of uric acid in mineral bone disorders in chronic kidney disease.

Published

Journal Article (Review)

Increasing survival in the chronic kidney disease (CKD) population exposes the bone to the cumulative detrimental sequelae of CKD, now defined physiologically and histopathologically as chronic kidney disease mineral bone disorder (CKD-BMD). This disorder is increasingly recognized as a "nontraditional" driver of morbidity and mortality and presents an opportunity to improve CKD outcomes via research. However, recent advances in the literature on this topic have not yet been collected into a single review. Therefore, this report aims to discuss the disordered renal-bone axis in CKD-BMD, molecular and hormonal drivers, novel treatment strategies, and forthcoming research in a clinician-directed format. A key novel topic will be the unique impact of uric acid on CKD-BMD, which is poised to apply extensive existing research in the uric acid domain to benefit the CKD-BMD population.

Full Text

Duke Authors

Cited Authors

  • Afsar, B; Sag, AA; Oztosun, C; Kuwabara, M; Cozzolino, M; Covic, A; Kanbay, M

Published Date

  • October 2019

Published In

Volume / Issue

  • 32 / 5

Start / End Page

  • 709 - 717

PubMed ID

  • 31030381

Pubmed Central ID

  • 31030381

Electronic International Standard Serial Number (EISSN)

  • 1724-6059

Digital Object Identifier (DOI)

  • 10.1007/s40620-019-00615-0

Language

  • eng

Conference Location

  • Italy