How Do Kidneys Adapt to a Deficit or Loss in Nephron Number?


Journal Article (Review)

A deficit or loss in the number of nephrons, the functional unit of the kidney, can induce compensatory growth and hyperfunction of remaining nephrons. An increase in single nephron glomerular filtration rate (SNGFR) aims to compensate but may be deleterious in the long term. The increase in SNGFR is determined by the dynamics of nephron loss, total remaining GFR, the body's excretory demand, and the functional capacity to sustain single nephron hyperfunction.

Full Text

Cited Authors

  • Fattah, H; Layton, A; Vallon, V

Published Date

  • May 2019

Published In

Volume / Issue

  • 34 / 3

Start / End Page

  • 189 - 197

PubMed ID

  • 30968755

Pubmed Central ID

  • 30968755

Electronic International Standard Serial Number (EISSN)

  • 1548-9221

International Standard Serial Number (ISSN)

  • 1548-9213

Digital Object Identifier (DOI)

  • 10.1152/physiol.00052.2018


  • eng