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Treatment of decompression sickness in swine with intravenous perfluorocarbon emulsion.

Publication ,  Journal Article
Dromsky, DM; Spiess, BD; Fahlman, A
Published in: Aviation, space, and environmental medicine
April 2004

We examined an adjunctive treatment for severe decompression sickness (DCS) to be used when hyperbaric treatment is delayed or unavailable.It has been hypothesized that intravenous perfluorocarbon (PFC) emulsion combined with 100% inspired O2 would improve the outcome in severe DCS.Swine (n = 45) were compressed to 4.9 ATA on air for 22 h and brought directly to 1 ATA at 0.9 ATA min(-1). The animals were then randomized to three groups. The first group breathed ambient air, the second group breathed 100% O2, and a third group received 6 ml x kg(-1) of perflubron emulsion (Oxygent) intravenously and breathed 100% O2. Outcomes of neurological and cardiopulmonary DCS and death were recorded.Animals that received PFC emulsion sustained less DCS (p < 0.01) than the other groups (53% vs. 93%). No animals in the PFC group sustained neurological DCS, which was present in 69% of the subjects in the other two groups.O2 breathing postdive did not significantly reduce morbidity or mortality in this model. Postdive treatment with PFC emulsion and 100% O2 decreased the incidence of DCS after nonstop decompression from saturation.

Duke Scholars

Published In

Aviation, space, and environmental medicine

EISSN

1943-4448

ISSN

0095-6562

Publication Date

April 2004

Volume

75

Issue

4

Start / End Page

301 / 305

Related Subject Headings

  • Swine
  • Random Allocation
  • Physiology
  • Male
  • Fluorocarbons
  • Emulsions
  • Decompression Sickness
  • Animals
  • 1117 Public Health and Health Services
  • 1116 Medical Physiology
 

Citation

APA
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ICMJE
MLA
NLM
Dromsky, D. M., Spiess, B. D., & Fahlman, A. (2004). Treatment of decompression sickness in swine with intravenous perfluorocarbon emulsion. Aviation, Space, and Environmental Medicine, 75(4), 301–305.
Dromsky, David M., Bruce D. Spiess, and Andreas Fahlman. “Treatment of decompression sickness in swine with intravenous perfluorocarbon emulsion.Aviation, Space, and Environmental Medicine 75, no. 4 (April 2004): 301–5.
Dromsky DM, Spiess BD, Fahlman A. Treatment of decompression sickness in swine with intravenous perfluorocarbon emulsion. Aviation, space, and environmental medicine. 2004 Apr;75(4):301–5.
Dromsky, David M., et al. “Treatment of decompression sickness in swine with intravenous perfluorocarbon emulsion.Aviation, Space, and Environmental Medicine, vol. 75, no. 4, Apr. 2004, pp. 301–05.
Dromsky DM, Spiess BD, Fahlman A. Treatment of decompression sickness in swine with intravenous perfluorocarbon emulsion. Aviation, space, and environmental medicine. 2004 Apr;75(4):301–305.

Published In

Aviation, space, and environmental medicine

EISSN

1943-4448

ISSN

0095-6562

Publication Date

April 2004

Volume

75

Issue

4

Start / End Page

301 / 305

Related Subject Headings

  • Swine
  • Random Allocation
  • Physiology
  • Male
  • Fluorocarbons
  • Emulsions
  • Decompression Sickness
  • Animals
  • 1117 Public Health and Health Services
  • 1116 Medical Physiology