Shifting Paradigms in Allergic Contact Dermatitis: The Role of Innate Immunity.

Journal Article (Journal Article;Review)

The role of the innate immune system in allergic contact dermatitis (ACD) has traditionally been confined to the initial antigen sensitization phase. However, more recent findings have shown the role of innate immunity in additional aspects of ACD, including the effector phase of the classic type IV hypersensitivity reaction. As a result, the precise immunologic mechanisms mediating ACD are more complex than previously believed. The aim of this review is to provide insight into recent advances in understanding the role of the innate immune system in the pathogenesis of ACD, including novel mechanistic roles for macrophages, innate lymphoid cells, natural killer cells, innate γδ T cells, and other signaling molecules. These insights provide new opportunities for therapeutic intervention in ACD.

Full Text

Duke Authors

Cited Authors

  • Brys, AK; Rodriguez-Homs, LG; Suwanpradid, J; Atwater, AR; MacLeod, AS

Published Date

  • January 2020

Published In

Volume / Issue

  • 140 / 1

Start / End Page

  • 21 - 28

PubMed ID

  • 31101475

Pubmed Central ID

  • 31101475

Electronic International Standard Serial Number (EISSN)

  • 1523-1747

Digital Object Identifier (DOI)

  • 10.1016/j.jid.2019.03.1133


  • eng

Conference Location

  • United States