Heart Failure and Atrial Fibrillation, Like Fire and Fury.


Journal Article (Review)

Heart failure and atrial fibrillation are 2 common cardiovascular disorders that frequently complicate one another and exert a significant detrimental effect on cardiovascular health and well-being. Both heart failure and atrial fibrillation continue to increase in prevalence as the risk factors underlying each condition become more common. This review encompasses what is currently known about the epidemiology and pathophysiology of these comorbidities along with incorporation of landmark trials that have contributed to current guidelines. The focus is on clinically relevant considerations, including the contribution of inflammation in the pathophysiology of atrial fibrillation and heart failure. We explore the emerging role of catheter ablation relative to medical therapy in the management of heart failure with reduced ejection fraction, along with indications for biventricular pacing modalities in cardiac resynchronization therapy. We discuss current guideline-directed therapies and how practice models and national recommendations will likely change based on the most recent randomized controlled trials.

Full Text

Duke Authors

Cited Authors

  • Carlisle, MA; Fudim, M; DeVore, AD; Piccini, JP

Published Date

  • June 2019

Published In

Volume / Issue

  • 7 / 6

Start / End Page

  • 447 - 456

PubMed ID

  • 31146871

Pubmed Central ID

  • 31146871

Electronic International Standard Serial Number (EISSN)

  • 2213-1787

Digital Object Identifier (DOI)

  • 10.1016/j.jchf.2019.03.005


  • eng

Conference Location

  • United States