The Genomic Medicine Integrative Research Framework: A Conceptual Framework for Conducting Genomic Medicine Research.
Journal Article (Journal Article)
Conceptual frameworks are useful in research because they can highlight priority research domains, inform decisions about interventions, identify outcomes and factors to measure, and display how factors might relate to each other to generate and test hypotheses. Discovery, translational, and implementation research are all critical to the overall mission of genomic medicine and prevention, but they have yet to be organized into a unified conceptual framework. To fill this gap, our diverse team collaborated to develop the Genomic Medicine Integrative Research (GMIR) Framework, a simple but comprehensive tool to aid the genomics community in developing research questions, strategies, and measures and in integrating genomic medicine and prevention into clinical practice. Here we present the GMIR Framework and its development, along with examples of its use for research development, demonstrating how we applied it to select and harmonize measures for use across diverse genomic medicine implementation projects. Researchers can utilize the GMIR Framework for their own research, collaborative investigations, and clinical implementation efforts; clinicians can use it to establish and evaluate programs; and all stakeholders can use it to help allocate resources and make sure that the full complexity of etiology is included in research and program design, development, and evaluation.
Full Text
Duke Authors
Cited Authors
- Horowitz, CR; Orlando, LA; Slavotinek, AM; Peterson, J; Angelo, F; Biesecker, B; Bonham, VL; Cameron, LD; Fullerton, SM; Gelb, BD; Goddard, KAB; Hailu, B; Hart, R; Hindorff, LA; Jarvik, GP; Kaufman, D; Kenny, EE; Knight, SJ; Koenig, BA; Korf, BR; Madden, E; McGuire, AL; Ou, J; Wasserstein, MP; Robinson, M; Leventhal, H; Sanderson, SC
Published Date
- June 6, 2019
Published In
Volume / Issue
- 104 / 6
Start / End Page
- 1088 - 1096
PubMed ID
- 31104772
Pubmed Central ID
- PMC6556906
Electronic International Standard Serial Number (EISSN)
- 1537-6605
Digital Object Identifier (DOI)
- 10.1016/j.ajhg.2019.04.006
Language
- eng
Conference Location
- United States