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Defining Clinically Important Difference in the Atrial Fibrillation Effect on Quality-of-Life Score.

Publication ,  Journal Article
Holmes, DN; Piccini, JP; Allen, LA; Fonarow, GC; Gersh, BJ; Kowey, PR; O'Brien, EC; Reiffel, JA; Naccarelli, GV; Ezekowitz, MD; Chan, PS ...
Published in: Circ Cardiovasc Qual Outcomes
May 2019

Background The Atrial Fibrillation Effect on Quality-of-Life (AFEQT) questionnaire has recently been validated to measure the impact of atrial fibrillation on quality of life, but a clinically important difference in AFEQT score has not been well defined. Methods and Results To determine the clinically important difference in overall AFEQT (score range= 0 [worst] to 100 [best]) and selected subscales, we analyzed data in the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry, a United States-based outpatient atrial fibrillation registry. AFEQT was assessed at baseline and 1 year in a subset of 1347 ORBIT-AF patients from 80 US sites participating in ORBIT-AF from June 2010 to August 2011. The mean change method was used to relate changes in 1-year AFEQT scores to clinically important changes in the physician assessment of European Heart Rhythm Association functional status (1 class improvement and separately 1 class deterioration). Clinically important differences and 95% CI corresponding to either a 1 European Heart Rhythm Association class improvement or deterioration were 5.4 (3.6-7.2) and -4.2 (-6.9 to -1.5) AFEQT points, respectively. Similarly, clinically important difference values were seen for a 1 European Heart Rhythm Association class improvement for the AFEQT subscales Activities of Daily Living and Symptoms: 5.1 (2.5-7.6) and 7.1 (5.3-9.0) AFEQT points, respectively. Conclusions Based on the anchor of 1 European Heart Rhythm Association class change, changes in AFEQT score of + or -5 points are clinically important changes in patients' health. Clinical Trial Registration URL: https://clinicaltrials.gov . Unique identifier: NCT01165710.

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Published In

Circ Cardiovasc Qual Outcomes

DOI

EISSN

1941-7705

Publication Date

May 2019

Volume

12

Issue

5

Start / End Page

e005358

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Time Factors
  • Surveys and Questionnaires
  • Registries
  • Recovery of Function
  • Quality of Life
  • Predictive Value of Tests
  • Minimal Clinically Important Difference
  • Male
 

Citation

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Holmes, D. N., Piccini, J. P., Allen, L. A., Fonarow, G. C., Gersh, B. J., Kowey, P. R., … Thomas, L. (2019). Defining Clinically Important Difference in the Atrial Fibrillation Effect on Quality-of-Life Score. Circ Cardiovasc Qual Outcomes, 12(5), e005358. https://doi.org/10.1161/CIRCOUTCOMES.118.005358
Holmes, DaJuanicia N., Jonathan P. Piccini, Larry A. Allen, Gregg C. Fonarow, Bernard J. Gersh, Peter R. Kowey, Emily C. O’Brien, et al. “Defining Clinically Important Difference in the Atrial Fibrillation Effect on Quality-of-Life Score.Circ Cardiovasc Qual Outcomes 12, no. 5 (May 2019): e005358. https://doi.org/10.1161/CIRCOUTCOMES.118.005358.
Holmes DN, Piccini JP, Allen LA, Fonarow GC, Gersh BJ, Kowey PR, et al. Defining Clinically Important Difference in the Atrial Fibrillation Effect on Quality-of-Life Score. Circ Cardiovasc Qual Outcomes. 2019 May;12(5):e005358.
Holmes, DaJuanicia N., et al. “Defining Clinically Important Difference in the Atrial Fibrillation Effect on Quality-of-Life Score.Circ Cardiovasc Qual Outcomes, vol. 12, no. 5, May 2019, p. e005358. Pubmed, doi:10.1161/CIRCOUTCOMES.118.005358.
Holmes DN, Piccini JP, Allen LA, Fonarow GC, Gersh BJ, Kowey PR, O’Brien EC, Reiffel JA, Naccarelli GV, Ezekowitz MD, Chan PS, Singer DE, Spertus JA, Peterson ED, Thomas L. Defining Clinically Important Difference in the Atrial Fibrillation Effect on Quality-of-Life Score. Circ Cardiovasc Qual Outcomes. 2019 May;12(5):e005358.

Published In

Circ Cardiovasc Qual Outcomes

DOI

EISSN

1941-7705

Publication Date

May 2019

Volume

12

Issue

5

Start / End Page

e005358

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Time Factors
  • Surveys and Questionnaires
  • Registries
  • Recovery of Function
  • Quality of Life
  • Predictive Value of Tests
  • Minimal Clinically Important Difference
  • Male