Biodistribution and sensitive tracking of immune cells with plasmonic gold nanostars.

Journal Article (Journal Article)

Aim: To quantitatively and sensitively investigate the biodistribution of immune cells after systemic administration. Methods: Immune cells were loaded with plasmonic gold nanostars (GNS) tracking probes. Inductively coupled plasma mass spectrometry (ICP-MS) was used for quantitative gold mass measurement and two-photon photoluminescence (TPL) was used for high-resolution sensitive optical imaging. Results: GNS nanoparticles were loaded successfully into immune cells without negative effect on cellular vitality. Liver and spleen were identified to be the major organs for macrophage cells uptake after systematic administration. A small amount of macrophage cells were detected in the tumor site in our murine lymphoma animal model. Conclusion: GNS has great potential as a biocompatible marker for quantitative tracking and high-resolution imaging of immune cells at the cellular level.

Full Text

Duke Authors

Cited Authors

  • Liu, Y; Huang, W; Xiong, C; Huang, Y; Chen, BJ; Racioppi, L; Chao, N; Vo-Dinh, T

Published Date

  • 2019

Published In

Volume / Issue

  • 14 /

Start / End Page

  • 3403 - 3411

PubMed ID

  • 31190799

Pubmed Central ID

  • PMC6514259

Electronic International Standard Serial Number (EISSN)

  • 1178-2013

Digital Object Identifier (DOI)

  • 10.2147/IJN.S192189


  • eng

Conference Location

  • New Zealand