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Biodistribution and sensitive tracking of immune cells with plasmonic gold nanostars.

Publication ,  Journal Article
Liu, Y; Huang, W; Xiong, C; Huang, Y; Chen, BJ; Racioppi, L; Chao, N; Vo-Dinh, T
Published in: Int J Nanomedicine
2019

Aim: To quantitatively and sensitively investigate the biodistribution of immune cells after systemic administration. Methods: Immune cells were loaded with plasmonic gold nanostars (GNS) tracking probes. Inductively coupled plasma mass spectrometry (ICP-MS) was used for quantitative gold mass measurement and two-photon photoluminescence (TPL) was used for high-resolution sensitive optical imaging. Results: GNS nanoparticles were loaded successfully into immune cells without negative effect on cellular vitality. Liver and spleen were identified to be the major organs for macrophage cells uptake after systematic administration. A small amount of macrophage cells were detected in the tumor site in our murine lymphoma animal model. Conclusion: GNS has great potential as a biocompatible marker for quantitative tracking and high-resolution imaging of immune cells at the cellular level.

Duke Scholars

Published In

Int J Nanomedicine

DOI

EISSN

1178-2013

Publication Date

2019

Volume

14

Start / End Page

3403 / 3411

Location

New Zealand

Related Subject Headings

  • Tissue Distribution
  • Nanoscience & Nanotechnology
  • Mice, Inbred C57BL
  • Metal Nanoparticles
  • Macrophages
  • Lymphocytes
  • Gold
  • Cell Survival
  • Cell Line, Tumor
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Liu, Y., Huang, W., Xiong, C., Huang, Y., Chen, B. J., Racioppi, L., … Vo-Dinh, T. (2019). Biodistribution and sensitive tracking of immune cells with plasmonic gold nanostars. Int J Nanomedicine, 14, 3403–3411. https://doi.org/10.2147/IJN.S192189
Liu, Yang, Wei Huang, Chuanfeng Xiong, Yuxian Huang, Benny J. Chen, Luigi Racioppi, Nelson Chao, and Tuan Vo-Dinh. “Biodistribution and sensitive tracking of immune cells with plasmonic gold nanostars.Int J Nanomedicine 14 (2019): 3403–11. https://doi.org/10.2147/IJN.S192189.
Liu Y, Huang W, Xiong C, Huang Y, Chen BJ, Racioppi L, et al. Biodistribution and sensitive tracking of immune cells with plasmonic gold nanostars. Int J Nanomedicine. 2019;14:3403–11.
Liu, Yang, et al. “Biodistribution and sensitive tracking of immune cells with plasmonic gold nanostars.Int J Nanomedicine, vol. 14, 2019, pp. 3403–11. Pubmed, doi:10.2147/IJN.S192189.
Liu Y, Huang W, Xiong C, Huang Y, Chen BJ, Racioppi L, Chao N, Vo-Dinh T. Biodistribution and sensitive tracking of immune cells with plasmonic gold nanostars. Int J Nanomedicine. 2019;14:3403–3411.

Published In

Int J Nanomedicine

DOI

EISSN

1178-2013

Publication Date

2019

Volume

14

Start / End Page

3403 / 3411

Location

New Zealand

Related Subject Headings

  • Tissue Distribution
  • Nanoscience & Nanotechnology
  • Mice, Inbred C57BL
  • Metal Nanoparticles
  • Macrophages
  • Lymphocytes
  • Gold
  • Cell Survival
  • Cell Line, Tumor
  • Animals