An update on Burkitt lymphoma: a review of pathogenesis and multimodality imaging assessment of disease presentation, treatment response, and recurrence.

Journal Article (Review;Journal Article)

Burkitt lymphoma (BL) is a highly aggressive, rapidly growing B cell non-Hodgkin lymphoma, which manifests in several subtypes including sporadic, endemic, and immunodeficiency-associated forms. Pathologically, BL is classically characterized by translocations of chromosomes 8 and 14 resulting in upregulation of the c-myc protein transcription factor with upregulation of cell proliferation. BL affects nearly every organ system, most commonly the abdomen and pelvis in the sporadic form. Imaging using a multimodality approach plays a crucial role in the management of BL from diagnosis, staging, and evaluation of treatment response to therapy-related complications with ultrasound, computed tomography, magnetic resonance imaging, and positron emission tomography playing roles. In this article, we review the pathobiology and classification of BL, illustrate a multimodality imaging approach in evaluating common and uncommon sites of involvement within the trunk and head and neck, and review common therapies and treatment-related complications.

Full Text

Duke Authors

Cited Authors

  • Kalisz, K; Alessandrino, F; Beck, R; Smith, D; Kikano, E; Ramaiya, NH; Tirumani, SH

Published Date

  • May 2019

Published In

Volume / Issue

  • 10 / 1

Start / End Page

  • 56 -

PubMed ID

  • 31115699

Pubmed Central ID

  • PMC6529494

Electronic International Standard Serial Number (EISSN)

  • 1869-4101

International Standard Serial Number (ISSN)

  • 1869-4101

Digital Object Identifier (DOI)

  • 10.1186/s13244-019-0733-7


  • eng