Updating Neuroimmune Targets in Central Nervous System Dysfunction.


Journal Article (Review)

Disorders of the central nervous system (CNS) have many etiologies compounded by limited options for treatment. The lack of successful treatments for these disorders stems from the difficulty of gaining effective access to the CNS through the blood-brain barrier, and the irreplaceable nature of neurons. Here, we review recent advances in the field of neuroimmunology and discuss novel strategies for targeting microglia, meningeal lymphatics, and the peripheral immune system that may lead to successful treatment of a broad range of CNS disorders. In the future, it will be important to continue to explore the vast communications between the CNS and the immune system to map out dysfunctions that attribute to diseases such as chronic neuroinflammation, autoimmunity, CNS injury, and more.

Full Text

Duke Authors

Cited Authors

  • Valente, LA; Begg, LR; Filiano, AJ

Published Date

  • July 2019

Published In

Volume / Issue

  • 40 / 7

Start / End Page

  • 482 - 494

PubMed ID

  • 31130220

Pubmed Central ID

  • 31130220

Electronic International Standard Serial Number (EISSN)

  • 1873-3735

Digital Object Identifier (DOI)

  • 10.1016/j.tips.2019.04.013


  • eng

Conference Location

  • England