Mitochondrial alterations may underlie race-specific differences in cancer risk and outcome.

Journal Article (Journal Article)

African Americans are at increased risk of cancer and associated mortalities compared with European American populations. Socioeconomic, cultural, and biological factors have been implicated in this discrepancy. In this issue of the JCI, Piyarathna et al. identify a set of genes that are upregulated in a number of tumor types in African American cancer patients as compared with European American patients. These genes were associated with enhanced oxidative phosphorylation and upregulation of transcription factors that promote mitochondrial biogenesis, resulting in greater numbers of mitochondria in tumor samples from African American subjects. Together, these results indicate that mitochondria dysfunction may underlie the increased cancer incidence and poor outcomes observed in African American patients.

Full Text

Duke Authors

Cited Authors

  • Beebe-Dimmer, JL; Cooney, KA

Published Date

  • May 6, 2019

Published In

Volume / Issue

  • 129 / 6

Start / End Page

  • 2187 - 2188

PubMed ID

  • 31063989

Pubmed Central ID

  • PMC6546466

Electronic International Standard Serial Number (EISSN)

  • 1558-8238

Digital Object Identifier (DOI)

  • 10.1172/JCI128707


  • eng

Conference Location

  • United States