Deprescribing in Older Adults With Cardiovascular Disease.


Journal Article (Review)

Deprescribing, an integral component of a continuum of good prescribing practices, is the process of medication withdrawal or dose reduction to correct or prevent medication-related complications, improve outcomes, and reduce costs. Deprescribing is particularly applicable to the commonly encountered multimorbid older adult with cardiovascular disease and concomitant geriatric conditions such as polypharmacy, frailty, and cognitive dysfunction-a combination rarely addressed in current clinical practice guidelines. Triggers to deprescribe include present or expected adverse drug reactions, unnecessary polypharmacy, and the need to align medications with goals of care when life expectancy is reduced. Using a framework to deprescribe, this review addresses the rationale, evidence, and strategies for deprescribing cardiovascular and some noncardiovascular medications.

Full Text

Duke Authors

Cited Authors

  • Krishnaswami, A; Steinman, MA; Goyal, P; Zullo, AR; Anderson, TS; Birtcher, KK; Goodlin, SJ; Maurer, MS; Alexander, KP; Rich, MW; Tjia, J; Geriatric Cardiology Section Leadership Council, American College of Cardiology,

Published Date

  • May 28, 2019

Published In

Volume / Issue

  • 73 / 20

Start / End Page

  • 2584 - 2595

PubMed ID

  • 31118153

Pubmed Central ID

  • 31118153

Electronic International Standard Serial Number (EISSN)

  • 1558-3597

Digital Object Identifier (DOI)

  • 10.1016/j.jacc.2019.03.467


  • eng

Conference Location

  • United States