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Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes.

Publication ,  Journal Article
Laville, V; Kang, JH; Cousins, CC; Iglesias, AI; Nagy, R; Cooke Bailey, JN; Igo, RP; Song, YE; Chasman, DI; Christen, WG; Kraft, P; Rosner, BA ...
Published in: Am J Ophthalmol
October 2019

PURPOSE: A genetic correlation is the proportion of phenotypic variance between traits that is shared on a genetic basis. Here we explore genetic correlations between diabetes- and glaucoma-related traits. DESIGN: Cross-sectional study. METHODS: We assembled genome-wide association study summary statistics from European-derived participants regarding diabetes-related traits like fasting blood sugar (FBS) and type 2 diabetes (T2D) and glaucoma-related traits (intraocular pressure [IOP], central corneal thickness [CCT], corneal hysteresis [CH], corneal resistance factor [CRF], cup-to-disc ratio [CDR], and primary open-angle glaucoma [POAG]). We included data from the National Eye Institute Glaucoma Human Genetics Collaboration Heritable Overall Operational Database, the UK Biobank, and the International Glaucoma Genetics Consortium. We calculated genetic correlation (rg) between traits using linkage disequilibrium score regression. We also calculated genetic correlations between IOP, CCT, and select diabetes-related traits based on individual level phenotype data in 2 Northern European population-based samples using pedigree information and Sequential Oligogenic Linkage Analysis Routines. RESULTS: Overall, there was little rg between diabetes- and glaucoma-related traits. Specifically, we found a nonsignificant negative correlation between T2D and POAG (rg = -0.14; P = .16). Using Sequential Oligogenic Linkage Analysis Routines, the genetic correlations between measured IOP, CCT, FBS, fasting insulin, and hemoglobin A1c were null. In contrast, genetic correlations between IOP and POAG (rg ≥ 0.45; P ≤ 3.0 × 10-4) and between CDR and POAG were high (rg = 0.57; P = 2.8 × 10-10). However, genetic correlations between corneal properties (CCT, CRF, and CH) and POAG were low (rg range -0.18 to 0.11) and nonsignificant (P ≥ .07). CONCLUSION: These analyses suggest that there is limited genetic correlation between diabetes- and glaucoma-related traits.

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Published In

Am J Ophthalmol

DOI

EISSN

1879-1891

Publication Date

October 2019

Volume

206

Start / End Page

245 / 255

Location

United States

Related Subject Headings

  • Young Adult
  • United States
  • Tonometry, Ocular
  • Phenotype
  • Pedigree
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Intraocular Pressure
  • Incidence
 

Citation

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MLA
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Laville, V., Kang, J. H., Cousins, C. C., Iglesias, A. I., Nagy, R., Cooke Bailey, J. N., … NEIGHBORHOOD Consortium, . (2019). Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes. Am J Ophthalmol, 206, 245–255. https://doi.org/10.1016/j.ajo.2019.05.015
Laville, Vincent, Jae H. Kang, Clara C. Cousins, Adriana I. Iglesias, Réka Nagy, Jessica N. Cooke Bailey, Robert P. Igo, et al. “Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes.Am J Ophthalmol 206 (October 2019): 245–55. https://doi.org/10.1016/j.ajo.2019.05.015.
Laville V, Kang JH, Cousins CC, Iglesias AI, Nagy R, Cooke Bailey JN, et al. Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes. Am J Ophthalmol. 2019 Oct;206:245–55.
Laville, Vincent, et al. “Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes.Am J Ophthalmol, vol. 206, Oct. 2019, pp. 245–55. Pubmed, doi:10.1016/j.ajo.2019.05.015.
Laville V, Kang JH, Cousins CC, Iglesias AI, Nagy R, Cooke Bailey JN, Igo RP, Song YE, Chasman DI, Christen WG, Kraft P, Rosner BA, Hu F, Wilson JF, Gharahkhani P, Hewitt AW, Mackey DA, Hysi PG, Hammond CJ, vanDuijn CM, Haines JL, Vitart V, Fingert JH, Hauser MA, Aschard H, Wiggs JL, Khawaja AP, MacGregor S, Pasquale LR, UK Biobank, International Glaucoma Genetics Consortium, NEIGHBORHOOD Consortium. Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes. Am J Ophthalmol. 2019 Oct;206:245–255.
Journal cover image

Published In

Am J Ophthalmol

DOI

EISSN

1879-1891

Publication Date

October 2019

Volume

206

Start / End Page

245 / 255

Location

United States

Related Subject Headings

  • Young Adult
  • United States
  • Tonometry, Ocular
  • Phenotype
  • Pedigree
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Intraocular Pressure
  • Incidence