Acetate Metabolism in Physiology, Cancer, and Beyond.

Journal Article (Journal Article;Review)

Acetate and the related metabolism of acetyl-coenzyme A (acetyl-CoA) confer numerous metabolic functions, including energy production, lipid synthesis, and protein acetylation. Despite its importance as a nutrient for cellular metabolism, its source has been unclear. Recent studies have provided evidence to support the existence of a de novo pathway for acetate production derived from pyruvate, the end product of glycolysis. This mechanism of pyruvate-derived acetate generation could have far-reaching implications for the regulation of central carbon metabolism. In this Opinion, we discuss our current understanding of acetate metabolism in the context of cell-autonomous metabolic regulation, cell-cell interactions, and systemic physiology. Applications relevant to health and disease, particularly cancer, are emphasized.

Full Text

Duke Authors

Cited Authors

  • Bose, S; Ramesh, V; Locasale, JW

Published Date

  • September 2019

Published In

Volume / Issue

  • 29 / 9

Start / End Page

  • 695 - 703

PubMed ID

  • 31160120

Pubmed Central ID

  • PMC6699882

Electronic International Standard Serial Number (EISSN)

  • 1879-3088

Digital Object Identifier (DOI)

  • 10.1016/j.tcb.2019.05.005


  • eng

Conference Location

  • England