Type 2 Diabetes Mellitus and Heart Failure, A Scientific Statement From the American Heart Association and Heart Failure Society of America.

Journal Article (Journal Article;Review)

Type 2 diabetes mellitus is a risk factor for incident heart failure and increases the risk of morbidity and mortality in patients with established disease. Secular trends in the prevalence of diabetes mellitus and heart failure forecast a growing burden of disease and underscore the need for effective therapeutic strategies. Recent clinical trials have demonstrated the shared pathophysiology between diabetes mellitus and heart failure, the synergistic effect of managing both conditions, and the potential for diabetes mellitus therapies to modulate the risk of heart failure outcomes. This scientific statement on diabetes mellitus and heart failure summarizes the epidemiology, pathophysiology, and impact of diabetes mellitus and its control on outcomes in heart failure; reviews the approach to pharmacological therapy and lifestyle modification in patients with diabetes mellitus and heart failure; highlights the value of multidisciplinary interventions to improve clinical outcomes in this population; and outlines priorities for future research.

Full Text

Duke Authors

Cited Authors

  • Dunlay, SM; Givertz, MM; Aguilar, D; Allen, LA; Chan, M; Desai, AS; Deswal, A; Dickson, VV; Kosiborod, MN; Lekavich, CL; McCoy, RG; Mentz, RJ; PiÑa, IL; American Heart Association Heart Failure and Transplantation Committee of the Council on Clinical Cardiology, ; Council on Cardiovascular and Stroke Nursing, ; Heart Failure Society of America,

Published Date

  • August 2019

Published In

Volume / Issue

  • 25 / 8

Start / End Page

  • 584 - 619

PubMed ID

  • 31174952

Electronic International Standard Serial Number (EISSN)

  • 1532-8414

Digital Object Identifier (DOI)

  • 10.1016/j.cardfail.2019.05.007


  • eng

Conference Location

  • United States