Catalytic Strategies to Convert 2-Halopyridines to 2-Alkylpyridines


Journal Article (Review)

© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Over the past decade, improvements in synthetic technologies have increased the feasibility and practicality of the preparation of 2-alkylpyridines from 2-halopyridines. Advances in iron-, nickel, and palladium-catalysis have increased efficiency in the access of 2-alkylpyridines with traditional cross-coupling approaches. Additionally, the emergence of cross-electrophile coupling reactions and photoredox catalysis strategies have proven to be enabling technologies for the synthesis of 2-alkylpyridines. Nevertheless, these developments reveal remaining opportunities for more efficient, mild, and straightforward methods to access a broader range of 2-alkylpyridines from 2-halopyridines.

Full Text

Duke Authors

Cited Authors

  • Blackburn, JM; Roizen, JL

Published Date

  • July 1, 2019

Published In

Volume / Issue

  • 8 / 7

Start / End Page

  • 920 - 930

International Standard Serial Number (ISSN)

  • 2193-5807

Digital Object Identifier (DOI)

  • 10.1002/ajoc.201900163

Citation Source

  • Scopus