How I do it: Apalutamide use in non-metastatic castrate resistant prostate cancer.

Journal Article (Journal Article;Review)

Urologists have been using oral nonsteroidal antiandrogens (AA) for 30 years as a component of combined androgen blockade. In February 2018, a new third generation AA, apalutamide, became available for the first time for non-metastatic (M0) castrate resistant prostate cancer (CRPC). Apalutamide was found to delay the presence of metastases (metastases free survival-MFS) by approximately 2 years versus placebo in M0 CRPC. While overall survival benefit has yet to be established, the MFS benefit is clinically meaningful and urology practices should be equipped to manage patients using this new oral agent. Since the majority of patients remain under urologic care when this disease stage develops and because the drug is straightforward to administer, urology practices are ideal to identify and treat. The objective of this brief article is to discuss the typical patient profile for use of apalutamide and to review the pros and cons of use and common side effects and management.

Full Text

Duke Authors

Cited Authors

  • Moul, JW

Published Date

  • June 2019

Published In

Volume / Issue

  • 26 / 3

Start / End Page

  • 9782 - 9786

PubMed ID

  • 31180310

International Standard Serial Number (ISSN)

  • 1195-9479

Language

  • eng

Conference Location

  • Canada