CHML promotes liver cancer metastasis by facilitating Rab14 recycle.
Journal Article (Journal Article)
Metastasis-associated recurrence is the major cause of poor prognosis in hepatocellular carcinoma (HCC), however, the underlying mechanisms remain largely elusive. In this study, we report that expression of choroideremia-like (CHML) is increased in HCC, associated with poor survival, early recurrence and more satellite nodules in HCC patients. CHML promotes migration, invasion and metastasis of HCC cells, in a Rab14-dependent manner. Mechanism study reveals that CHML facilitates constant recycling of Rab14 by escorting Rab14 to the membrane. Furthermore, we identify several metastasis regulators as cargoes carried by Rab14-positive vesicles, including Mucin13 and CD44, which may contribute to metastasis-promoting effects of CHML. Altogether, our data establish CHML as a potential promoter of HCC metastasis, and the CHML-Rab14 axis may be a promising therapeutic target for HCC.
- Chen, T-W; Yin, F-F; Yuan, Y-M; Guan, D-X; Zhang, E; Zhang, F-K; Jiang, H; Ma, N; Wang, J-J; Ni, Q-Z; Qiu, L; Feng, J; Zhang, X-L; Bao, Y; Wang, K; Cheng, S-Q; Wang, X-F; Wang, X; Li, J-J; Xie, D
- June 7, 2019
Volume / Issue
- 10 / 1
Start / End Page
- 2510 -
Pubmed Central ID
Electronic International Standard Serial Number (EISSN)
Digital Object Identifier (DOI)