The past, present, and future of costimulation blockade in organ transplantation.

Journal Article (Journal Article;Review)

PURPOSE OF REVIEW: Manipulating costimulatory signals has been shown to alter T cell responses and prolong graft survival in solid organ transplantation. Our understanding of and ability to target various costimulation pathways continues to evolve. RECENT FINDINGS: Since the approval of belatacept in kidney transplantation, many additional biologics have been developed targeting clinically relevant costimulation signaling axes including CD40-CD40L, inducible costimulator-inducible costimulator ligand (ICOS-ICOSL), and OX40-OX40L. Currently, the effects of costimulation blockade on posttransplant humoral responses, tolerance induction, and xenotransplantation are under active investigation. Here, we will discuss these pathways as well as preclinical and clinical outcomes of biologics targeting these pathways in organ transplantation. SUMMARY: Targeting costimultion is a promising approach for not only controlling T cell but also B cell responses. Consequently, costimulation blockade shows considerable potential for improving outcomes in antibody-mediated rejection and xenotransplantation.

Full Text

Duke Authors

Cited Authors

  • Schroder, PM; Fitch, ZW; Schmitz, R; Choi, AY; Kwun, J; Knechtle, SJ

Published Date

  • August 2019

Published In

Volume / Issue

  • 24 / 4

Start / End Page

  • 391 - 401

PubMed ID

  • 31157670

Pubmed Central ID

  • PMC7088447

Electronic International Standard Serial Number (EISSN)

  • 1531-7013

Digital Object Identifier (DOI)

  • 10.1097/MOT.0000000000000656


  • eng

Conference Location

  • United States