Moving Microbiome Science from the Bench to the Bedside: a Physician-Scientist Perspective.

Published online

Journal Article

The recognition over the past decade that nearly all diseases are associated with changes in the microbiome has raised hope that microbiome-based therapeutics may cure many human ailments. Billions of dollars are being poured into microbiome-oriented biotech companies, and the coming years will undoubtedly witness the approval of the first generation of these products. However, significant hurdles remain in expanding the pipeline and advancing these first-generation therapies. In this perspective, I will discuss the challenges related to identifying causal microbes, determining their mechanism of action, and characterizing the specific bacterial molecules required for disease protection. We are approaching these issues through a combination of clinical sampling, animal models, classic microbiology methodologies, and systems-based approaches. The field of microbiome research is on the cusp of being able to identify clinically actionable host-microbe relationships; increasing attention on identifying causal microbes and their bioactive factors will usher in the next generation of microbiome-based therapies.

Full Text

Duke Authors

Cited Authors

  • Surana, NK

Published Date

  • May 28, 2019

Published In

Volume / Issue

  • 4 / 3

PubMed ID

  • 31138724

Pubmed Central ID

  • 31138724

International Standard Serial Number (ISSN)

  • 2379-5077

Digital Object Identifier (DOI)

  • 10.1128/mSystems.00160-19

Language

  • eng

Conference Location

  • United States