Potent Anti-HIV Ingenane Diterpenoids from Euphorbia ebracteolata.

Journal Article (Journal Article)

Two new (1 and 2) and 14 known (3-16) ingenane diterpenoids were isolated from the roots of Euphorbia ebracteolata by bioassay-guided fractionation together with UPLC-MS n analysis. The absolute configurations of the new diterpenoids were established from electronic circular dichroism (ECD) data and ECD calculations. Except for ingenol (16), the ingenane diterpenoids with long aliphatic chain substituents (1-15) exhibited potent activities against HIV-1, with IC50 values of 0.7 to 9.7 nM and selectivity index values of 96.2 to 20 263. From the results, it was concluded that long aliphatic chain substituents are required for the enhanced anti-HIV activity of ingenane diterpenoids.

Full Text

Duke Authors

Cited Authors

  • Huang, Y-S; Lu, Y; Chen, C-H; Lee, K-H; Chen, D-F

Published Date

  • June 11, 2019

Published In

Volume / Issue

  • 82 / 6

Start / End Page

  • 1587 - 1592

PubMed ID

  • 31184480

Electronic International Standard Serial Number (EISSN)

  • 1520-6025

International Standard Serial Number (ISSN)

  • 0163-3864

Digital Object Identifier (DOI)

  • 10.1021/acs.jnatprod.9b00088


  • eng