Potent Anti-HIV Ingenane Diterpenoids from Euphorbia ebracteolata.
Published
Journal Article
Two new (1 and 2) and 14 known (3-16) ingenane diterpenoids were isolated from the roots of Euphorbia ebracteolata by bioassay-guided fractionation together with UPLC-MS n analysis. The absolute configurations of the new diterpenoids were established from electronic circular dichroism (ECD) data and ECD calculations. Except for ingenol (16), the ingenane diterpenoids with long aliphatic chain substituents (1-15) exhibited potent activities against HIV-1, with IC50 values of 0.7 to 9.7 nM and selectivity index values of 96.2 to 20 263. From the results, it was concluded that long aliphatic chain substituents are required for the enhanced anti-HIV activity of ingenane diterpenoids.
Full Text
Duke Authors
Cited Authors
- Huang, Y-S; Lu, Y; Chen, C-H; Lee, K-H; Chen, D-F
Published Date
- June 28, 2019
Published In
Volume / Issue
- 82 / 6
Start / End Page
- 1587 - 1592
PubMed ID
- 31184480
Pubmed Central ID
- 31184480
Electronic International Standard Serial Number (EISSN)
- 1520-6025
Digital Object Identifier (DOI)
- 10.1021/acs.jnatprod.9b00088
Language
- eng
Conference Location
- United States