Ethylene Glycol Toxicity in the Setting of Recurrent Ingestion: A Case Report and Literature Review.

Published online

Journal Article

Ethylene glycol (EG) poisoning is a toxicologic emergency requiring high clinical suspicion and early diagnosis to prevent life-threatening complications. Direct EG quantification methods involve cumbersome and time-consuming laboratory tests of limited utility in the emergency setting. Accordingly, the osmolal gap is frequently employed as a surrogate screening method in cases of suspected toxic alcohol poisoning. However, the osmolal gap has several inherent limitations to be considered when used as a diagnostic tool for EG toxicity. Although many of these limitations are widely acknowledged, the clinical finding of a normal serum osmolal gap in the setting of recurrent toxic alcohol exposure is an observation that has remained largely unexplored. The purpose of this case report is to characterize the accelerated osmolal gap to anion gap conversion that may occur in the setting of chronic toxic alcohol abuse.

Full Text

Duke Authors

Cited Authors

  • Loriaux, D; Bergin, SP; Patel, SM; Tucker, J; Barkauskas, CE

Published Date

  • April 3, 2019

Published In

Volume / Issue

  • 11 / 4

Start / End Page

  • e4375 -

PubMed ID

  • 31218140

Pubmed Central ID

  • 31218140

International Standard Serial Number (ISSN)

  • 2168-8184

Digital Object Identifier (DOI)

  • 10.7759/cureus.4375


  • eng

Conference Location

  • United States