A PheWAS approach in studying HLA-DRB1*1501.

Journal Article (Journal Article)

HLA-DRB1 codes for a major histocompatibility complex class II cell surface receptor. Genetic variants in and around this gene have been linked to numerous autoimmune diseases. Most notably, an association between HLA-DRB1*1501 haplotype and multiple sclerosis (MS) has been defined. Utilizing electronic health records and 4235 individuals within Marshfield Clinic's Personalized Medicine Research Project, a reverse genetic screen coined phenome-wide association study (PheWAS) tested association of rs3135388 genotype (tagging HLA-DRB1*1501) with 4841 phenotypes. As expected, HLA-DRB1*1501 was associated with MS (International Classification of Disease version 9-CM (ICD9) 340, P=0.023), whereas the strongest association was with alcohol-induced cirrhosis of the liver (ICD9 571.2, P=0.00011). HLA-DRB1*1501 also demonstrated association with erythematous conditions (ICD9 695, P=0.0054) and benign neoplasms of the respiratory and intrathoracic organs (ICD9 212, P=0.042), replicating previous findings. This study not only builds on the feasibility/utility of the PheWAS approach, represents the first external validation of a PheWAS, but may also demonstrate the complex etiologies associated with the HLA-DRB1*1501 loci.

Full Text

Duke Authors

Cited Authors

  • Hebbring, SJ; Schrodi, SJ; Ye, Z; Zhou, Z; Page, D; Brilliant, MH

Published Date

  • April 2013

Published In

Volume / Issue

  • 14 / 3

Start / End Page

  • 187 - 191

PubMed ID

  • 23392276

Pubmed Central ID

  • PMC3637423

Electronic International Standard Serial Number (EISSN)

  • 1476-5470

Digital Object Identifier (DOI)

  • 10.1038/gene.2013.2


  • eng

Conference Location

  • England