A probabilistic learning approach to whole-genome operon prediction.
Published
Journal Article
We present a computational approach to predicting operons in the genomes of prokaryotic organisms. Our approach uses machine learning methods to induce predictive models for this task from a rich variety of data types including sequence data, gene expression data, and functional annotations associated with genes. We use multiple learned models that individually predict promoters, terminators and operons themselves. A key part of our approach is a dynamic programming method that uses our predictions to map every known and putative gene in a given genome into its most probable operon. We evaluate our approach using data from the E. coli K-12 genome.
Full Text
Duke Authors
Cited Authors
- Craven, M; Page, D; Shavlik, J; Bockhorst, J; Glasner, J
Published Date
- 2000
Published In
Volume / Issue
- 8 /
Start / End Page
- 116 - 127
PubMed ID
- 10977072
Pubmed Central ID
- 10977072
International Standard Serial Number (ISSN)
- 1553-0833
Language
- eng
Conference Location
- United States