The Evolving Modern Management of Brain Metastasis.

Journal Article (Journal Article;Review)

The incidence of brain metastases is increasing as cancer therapies improve and patients live longer, providing new challenges to the multidisciplinary teams that care for these patients. Brain metastatic cancer cells possess unique characteristics that allow them to penetrate the blood-brain barrier, colonize the brain parenchyma, and persist in the intracranial environment. In addition, brain metastases subvert the innate and adaptive immune system, permitting evasion of the antitumor immune response. Better understanding of the above mechanisms will allow for development and delivery of more effective therapies for brain metastases. In this review, we outline the molecular mechanisms underlying development, survival, and immunosuppression of brain metastases. We also discuss current and emerging treatment strategies, including surgery, radiation, disease-specific and mutation-targeted systemic therapy, and immunotherapy.

Full Text

Duke Authors

Cited Authors

  • Fecci, PE; Champion, CD; Hoj, J; McKernan, CM; Goodwin, CR; Kirkpatrick, JP; Anders, CK; Pendergast, AM; Sampson, JH

Published Date

  • November 15, 2019

Published In

Volume / Issue

  • 25 / 22

Start / End Page

  • 6570 - 6580

PubMed ID

  • 31213459

Pubmed Central ID

  • PMC8258430

Electronic International Standard Serial Number (EISSN)

  • 1557-3265

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-18-1624


  • eng

Conference Location

  • United States