The Nuclear Pore Complex in Cell Type-Specific Chromatin Structure and Gene Regulation.

Journal Article (Journal Article;Review)

Nuclear pore complex (NPC)-mediated nucleocytoplasmic trafficking is essential for key cellular processes, such as cell growth, cell differentiation, and gene regulation. The NPC has also been viewed as a nuclear architectural platform that impacts genome function and gene expression by mediating spatial and temporal coordination between transcription factors, chromatin regulatory proteins, and transcription machinery. Recent findings have uncovered differential and cell type-specific expression and distinct chromatin-binding patterns of individual NPC components known as nucleoporins (Nups). Here, we examine recent studies that investigate the functional roles of NPCs and Nups in transcription, chromatin organization, and epigenetic gene regulation in the context of development and disease.

Full Text

Duke Authors

Cited Authors

  • Sun, J; Shi, Y; Yildirim, E

Published Date

  • August 2019

Published In

Volume / Issue

  • 35 / 8

Start / End Page

  • 579 - 588

PubMed ID

  • 31213386

International Standard Serial Number (ISSN)

  • 0168-9525

Digital Object Identifier (DOI)

  • 10.1016/j.tig.2019.05.006


  • eng

Conference Location

  • England