Skip to main content
Journal cover image

The Nuclear Pore Complex in Cell Type-Specific Chromatin Structure and Gene Regulation.

Publication ,  Journal Article
Sun, J; Shi, Y; Yildirim, E
Published in: Trends Genet
August 2019

Nuclear pore complex (NPC)-mediated nucleocytoplasmic trafficking is essential for key cellular processes, such as cell growth, cell differentiation, and gene regulation. The NPC has also been viewed as a nuclear architectural platform that impacts genome function and gene expression by mediating spatial and temporal coordination between transcription factors, chromatin regulatory proteins, and transcription machinery. Recent findings have uncovered differential and cell type-specific expression and distinct chromatin-binding patterns of individual NPC components known as nucleoporins (Nups). Here, we examine recent studies that investigate the functional roles of NPCs and Nups in transcription, chromatin organization, and epigenetic gene regulation in the context of development and disease.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Trends Genet

DOI

ISSN

0168-9525

Publication Date

August 2019

Volume

35

Issue

8

Start / End Page

579 / 588

Location

England

Related Subject Headings

  • Yeasts
  • Transcription, Genetic
  • Nucleic Acid Conformation
  • Nuclear Pore Complex Proteins
  • Nuclear Pore
  • Mice
  • Humans
  • Genome
  • Gene Expression Regulation
  • Epigenesis, Genetic
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sun, J., Shi, Y., & Yildirim, E. (2019). The Nuclear Pore Complex in Cell Type-Specific Chromatin Structure and Gene Regulation. Trends Genet, 35(8), 579–588. https://doi.org/10.1016/j.tig.2019.05.006
Sun, Jiayu, Yuming Shi, and Eda Yildirim. “The Nuclear Pore Complex in Cell Type-Specific Chromatin Structure and Gene Regulation.Trends Genet 35, no. 8 (August 2019): 579–88. https://doi.org/10.1016/j.tig.2019.05.006.
Sun J, Shi Y, Yildirim E. The Nuclear Pore Complex in Cell Type-Specific Chromatin Structure and Gene Regulation. Trends Genet. 2019 Aug;35(8):579–88.
Sun, Jiayu, et al. “The Nuclear Pore Complex in Cell Type-Specific Chromatin Structure and Gene Regulation.Trends Genet, vol. 35, no. 8, Aug. 2019, pp. 579–88. Pubmed, doi:10.1016/j.tig.2019.05.006.
Sun J, Shi Y, Yildirim E. The Nuclear Pore Complex in Cell Type-Specific Chromatin Structure and Gene Regulation. Trends Genet. 2019 Aug;35(8):579–588.
Journal cover image

Published In

Trends Genet

DOI

ISSN

0168-9525

Publication Date

August 2019

Volume

35

Issue

8

Start / End Page

579 / 588

Location

England

Related Subject Headings

  • Yeasts
  • Transcription, Genetic
  • Nucleic Acid Conformation
  • Nuclear Pore Complex Proteins
  • Nuclear Pore
  • Mice
  • Humans
  • Genome
  • Gene Expression Regulation
  • Epigenesis, Genetic