Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women.

Published

Journal Article

The placental transfer of maternal IgG is critical for infant protection against infectious pathogens. However, factors that modulate the placental transfer of IgG remain largely undefined. HIV-infected women have impaired placental IgG transfer, presenting a unique "disruption model" to define factors that modulate placental IgG transfer. We measured the placental transfer efficiency of maternal HIV and pathogen-specific IgG in US and Malawian HIV-infected mothers and their HIV-exposed uninfected and infected infants. We examined the role of maternal HIV disease progression, infant factors, placental Fc receptor expression, IgG subclass, and glycan signatures and their association with placental IgG transfer efficiency. Maternal IgG characteristics, such as binding to placentally expressed Fc receptors FcγRIIa and FcγRIIIa, and Fc region glycan profiles were associated with placental IgG transfer efficiency. Our findings suggest that Fc region characteristics modulate the selective placental transfer of IgG, with implications for maternal vaccine design and infant health.

Full Text

Duke Authors

Cited Authors

  • Martinez, DR; Fong, Y; Li, SH; Yang, F; Jennewein, MF; Weiner, JA; Harrell, EA; Mangold, JF; Goswami, R; Seage, GR; Alter, G; Ackerman, ME; Peng, X; Fouda, GG; Permar, SR

Published Date

  • June 27, 2019

Published In

Volume / Issue

  • 178 / 1

Start / End Page

  • 190 - 201.e11

PubMed ID

  • 31204101

Pubmed Central ID

  • 31204101

Electronic International Standard Serial Number (EISSN)

  • 1097-4172

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2019.05.046

Language

  • eng

Conference Location

  • United States