What risk of death would people take to be cured of HIV and why? A survey of people living with HIV.
People living with HIV (PLWHIV) can reasonably expect near-normal longevity, yet many express a willingness to assume significant risks to be cured. We surveyed 200 PLWHIV who were stable on antiretroviral therapy (ART) to quantify associations between the benefits they anticipate from a cure and their risk tolerance for curative treatments. Sixty-five per cent expected their health to improve if cured of HIV, 41% predicted the virus would stop responding to medications over the next 20 years and 54% predicted experiencing serious medication side effects in the next 20 years. Respondents' willingness to risk death for a cure varied widely (median 10%, 75th percentile 50%). In multivariate analyses, willingness to risk death was associated with expected long-term side effects of ART, greater financial resources and being employed (all P < 0.05) but was not associated with perceptions of how their health would improve if cured.
Murray, BR; Kratka, A; Scherr, KA; Eyal, N; Blumenthal-Barby, J; Freedberg, KA; Kuritzkes, DR; Hammitt, JK; Edifor, R; Katz, MN; Pollak, KI; Zikmund-Fisher, BJ; Halpern, SD; Barks, MC; Ubel, PA
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