Creatine supplementation reduces doxorubicin-induced cardiomyocellular injury.

Published

Journal Article

Heart failure is a common complication of doxorubicin (DOX) therapy. Previous studies have shown that DOX adversely impacts cardiac energy metabolism, and the ensuing energy deficiencies antedate clinical manifestations of cardiac toxicity. Brief exposure of cultured cardiomyocytes to DOX significantly decreases creatine transport, which is the cell's sole source of creatine. We present the results of a study performed to determine if physiological creatine supplementation (5 mmol/L) could protect cardiomyocytes in culture from cellular injury resulting from exposure to therapeutic levels of DOX. Creatine supplementation significantly decreased cytotoxicity, apoptosis, and reactive oxygen species production caused by DOX. The protective effect was specific to creatine and depended on its transport into the cell.

Full Text

Duke Authors

Cited Authors

  • Santacruz, L; Darrabie, MD; Mantilla, JG; Mishra, R; Feger, BJ; Jacobs, DO

Published Date

  • April 2015

Published In

Volume / Issue

  • 15 / 2

Start / End Page

  • 180 - 188

PubMed ID

  • 25253560

Pubmed Central ID

  • 25253560

Electronic International Standard Serial Number (EISSN)

  • 1559-0259

International Standard Serial Number (ISSN)

  • 1530-7905

Digital Object Identifier (DOI)

  • 10.1007/s12012-014-9283-x

Language

  • eng