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Creatine supplementation reduces doxorubicin-induced cardiomyocellular injury.

Publication ,  Journal Article
Santacruz, L; Darrabie, MD; Mantilla, JG; Mishra, R; Feger, BJ; Jacobs, DO
Published in: Cardiovascular toxicology
April 2015

Heart failure is a common complication of doxorubicin (DOX) therapy. Previous studies have shown that DOX adversely impacts cardiac energy metabolism, and the ensuing energy deficiencies antedate clinical manifestations of cardiac toxicity. Brief exposure of cultured cardiomyocytes to DOX significantly decreases creatine transport, which is the cell's sole source of creatine. We present the results of a study performed to determine if physiological creatine supplementation (5 mmol/L) could protect cardiomyocytes in culture from cellular injury resulting from exposure to therapeutic levels of DOX. Creatine supplementation significantly decreased cytotoxicity, apoptosis, and reactive oxygen species production caused by DOX. The protective effect was specific to creatine and depended on its transport into the cell.

Duke Scholars

Published In

Cardiovascular toxicology

DOI

EISSN

1559-0259

ISSN

1530-7905

Publication Date

April 2015

Volume

15

Issue

2

Start / End Page

180 / 188

Related Subject Headings

  • Rats, Sprague-Dawley
  • Rats
  • Myocytes, Cardiac
  • Doxorubicin
  • Creatine
  • Cells, Cultured
  • Cell Survival
  • Cardiovascular System & Hematology
  • Antibiotics, Antineoplastic
  • Animals, Newborn
 

Citation

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Santacruz, L., Darrabie, M. D., Mantilla, J. G., Mishra, R., Feger, B. J., & Jacobs, D. O. (2015). Creatine supplementation reduces doxorubicin-induced cardiomyocellular injury. Cardiovascular Toxicology, 15(2), 180–188. https://doi.org/10.1007/s12012-014-9283-x
Santacruz, Lucia, Marcus D. Darrabie, Jose Gabriel Mantilla, Rajashree Mishra, Bryan J. Feger, and Danny O. Jacobs. “Creatine supplementation reduces doxorubicin-induced cardiomyocellular injury.Cardiovascular Toxicology 15, no. 2 (April 2015): 180–88. https://doi.org/10.1007/s12012-014-9283-x.
Santacruz L, Darrabie MD, Mantilla JG, Mishra R, Feger BJ, Jacobs DO. Creatine supplementation reduces doxorubicin-induced cardiomyocellular injury. Cardiovascular toxicology. 2015 Apr;15(2):180–8.
Santacruz, Lucia, et al. “Creatine supplementation reduces doxorubicin-induced cardiomyocellular injury.Cardiovascular Toxicology, vol. 15, no. 2, Apr. 2015, pp. 180–88. Epmc, doi:10.1007/s12012-014-9283-x.
Santacruz L, Darrabie MD, Mantilla JG, Mishra R, Feger BJ, Jacobs DO. Creatine supplementation reduces doxorubicin-induced cardiomyocellular injury. Cardiovascular toxicology. 2015 Apr;15(2):180–188.
Journal cover image

Published In

Cardiovascular toxicology

DOI

EISSN

1559-0259

ISSN

1530-7905

Publication Date

April 2015

Volume

15

Issue

2

Start / End Page

180 / 188

Related Subject Headings

  • Rats, Sprague-Dawley
  • Rats
  • Myocytes, Cardiac
  • Doxorubicin
  • Creatine
  • Cells, Cultured
  • Cell Survival
  • Cardiovascular System & Hematology
  • Antibiotics, Antineoplastic
  • Animals, Newborn