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Admission oxygenation and ventilation parameters associated with discharge survival in severe pediatric traumatic brain injury.

Publication ,  Journal Article
Ramaiah, VK; Sharma, D; Ma, L; Prathep, S; Hoffman, NG; Vavilala, MS
Published in: Childs Nerv Syst
April 2013

PURPOSE: Current Brain Trauma Foundation guidelines recommend avoiding hypoxemia after severe pediatric traumatic brain injury (TBI). Yet, recent studies on optimum admission oxygenation and ventilation parameters associated with discharge survival in pediatric TBI are lacking. MATERIALS AND METHODS: After IRB approval, a retrospective study involving pediatric patients ages ≤14 years with severe TBI (head Abbreviated Injury Scale (AIS) score of ≥3, Glasgow Coma Scale score of ≤8 on admission) admitted to Harborview Medical Center (level 1 pediatric trauma center), Seattle, WA, during 2003 to 2007 was performed. Admission demographics, clinical data, and laboratory characteristics were abstracted. Hypoxemia was defined as PaO2 < 60 mmHg, hypocarbia was defined as PaCO2 ≤ 35 mmHg, and hypercarbia was defined as PaCO2 ≥ 46 mmHg. RESULTS: One hundred ninety-four patients met inclusion criteria of which 162 (83.5 %) patients survived. Admission hypoxemia occurred in nine (5.6 %) patients who survived and eight (25 %) patients who died (p < 0.001). Children with admission PaCO2 between 36 and 45 mmHg had greater discharge survival compared with those with both admission hypocarbia (PaCO2 ≤ 35 mmHg) and hypercarbia (PaCO2 ≥ 46 mmHg). Admission PaO2 301-500 mmHg (adjusted odds ratio (AOR), 8.02 (95 % confidence interval (CI), 1.73-37.10); p = 0.008) and admission PaCO2 = 36-45 mmHg (AOR, 5.47 (95 % CI, 1.30-23.07); p = 0.02) were independently associated with discharge survival. CONCLUSIONS: Discharge survival after severe pediatric TBI was associated with admission PaO2 301-500 mmHg and PaCO2 = 36-45 mmHg. Admission hypocarbia and hypercarbia were each associated with increased discharge mortality.

Duke Scholars

Published In

Childs Nerv Syst

DOI

EISSN

1433-0350

Publication Date

April 2013

Volume

29

Issue

4

Start / End Page

629 / 634

Location

Germany

Related Subject Headings

  • Treatment Outcome
  • Survival Rate
  • Retrospective Studies
  • Patient Discharge
  • Neurology & Neurosurgery
  • Male
  • Injury Severity Score
  • Infant
  • Hypoxia
  • Hypocapnia
 

Citation

APA
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ICMJE
MLA
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Ramaiah, V. K., Sharma, D., Ma, L., Prathep, S., Hoffman, N. G., & Vavilala, M. S. (2013). Admission oxygenation and ventilation parameters associated with discharge survival in severe pediatric traumatic brain injury. Childs Nerv Syst, 29(4), 629–634. https://doi.org/10.1007/s00381-012-1984-5
Ramaiah, Vijay Kumar, Deepak Sharma, Li Ma, Sumidtra Prathep, Noah G. Hoffman, and Monica S. Vavilala. “Admission oxygenation and ventilation parameters associated with discharge survival in severe pediatric traumatic brain injury.Childs Nerv Syst 29, no. 4 (April 2013): 629–34. https://doi.org/10.1007/s00381-012-1984-5.
Ramaiah VK, Sharma D, Ma L, Prathep S, Hoffman NG, Vavilala MS. Admission oxygenation and ventilation parameters associated with discharge survival in severe pediatric traumatic brain injury. Childs Nerv Syst. 2013 Apr;29(4):629–34.
Ramaiah, Vijay Kumar, et al. “Admission oxygenation and ventilation parameters associated with discharge survival in severe pediatric traumatic brain injury.Childs Nerv Syst, vol. 29, no. 4, Apr. 2013, pp. 629–34. Pubmed, doi:10.1007/s00381-012-1984-5.
Ramaiah VK, Sharma D, Ma L, Prathep S, Hoffman NG, Vavilala MS. Admission oxygenation and ventilation parameters associated with discharge survival in severe pediatric traumatic brain injury. Childs Nerv Syst. 2013 Apr;29(4):629–634.
Journal cover image

Published In

Childs Nerv Syst

DOI

EISSN

1433-0350

Publication Date

April 2013

Volume

29

Issue

4

Start / End Page

629 / 634

Location

Germany

Related Subject Headings

  • Treatment Outcome
  • Survival Rate
  • Retrospective Studies
  • Patient Discharge
  • Neurology & Neurosurgery
  • Male
  • Injury Severity Score
  • Infant
  • Hypoxia
  • Hypocapnia