Germline genetic landscape of pediatric central nervous system tumors.

Journal Article (Journal Article;Review)

Central nervous system (CNS) tumors are the second most common type of cancer among children. Depending on histopathology, anatomic location, and genomic factors, specific subgroups of brain tumors have some of the highest cancer-related mortality rates or result in considerable lifelong morbidity. Pediatric CNS tumors often occur in patients with genetic predisposition, at times revealing underlying cancer predisposition syndromes. Advances in next-generation sequencing (NGS) have resulted in the identification of an increasing number of cancer predisposition genes. In this review, the literature on genetic predisposition to pediatric CNS tumors is evaluated with a discussion of potential future targets for NGS and clinical implications. Furthermore, we explore potential strategies for enhancing the understanding of genetic predisposition of pediatric CNS tumors, including evaluation of non-European populations, pan-genomic approaches, and large collaborative studies.

Full Text

Duke Authors

Cited Authors

  • Muskens, IS; Zhang, C; de Smith, AJ; Biegel, JA; Walsh, KM; Wiemels, JL

Published Date

  • November 4, 2019

Published In

Volume / Issue

  • 21 / 11

Start / End Page

  • 1376 - 1388

PubMed ID

  • 31247102

Pubmed Central ID

  • PMC6827836

Electronic International Standard Serial Number (EISSN)

  • 1523-5866

Digital Object Identifier (DOI)

  • 10.1093/neuonc/noz108


  • eng

Conference Location

  • England