Validation of the triple timed up-and-go test in Lambert-Eaton myasthenia.

Journal Article (Journal Article)

INTRODUCTION: There are no validated, practical, and quantitative measures of disease severity in Lambert-Eaton myasthenia (LEM). METHODS: Data from the Effectiveness of 3,4-Diaminopyridine in Lambert-Eaton Myasthenic Syndrome (DAPPER) trial were analyzed to assess triple timed up-and-go (3TUG) reproducibility and relationships between 3TUG times and other measures of LEM severity. RESULTS: The coverage probability technique showed ≥0.90 probability for an acceptable 3TUG difference of ≤0.2, indicating that it is reproducible in LEM patients. The correlation between 3TUG times and lower extremity function scores was significant in subjects who continued and in those who were withdrawn from 3,4-diaminopyridine free base. Worsening patient-reported Weakness Self-Assessment Scale and Investigator Assessment of Treatment Effect scores corresponded with prolongation of 3TUG times. DISCUSSION: The 3TUG is reproducible, demonstrates construct validity for assessment of lower extremity function in LEM patients, and correlates with changes in patient and physician assessments. These findings, along with prior reliability studies, indicate 3TUG is a valid measure of disease severity in LEM.

Full Text

Duke Authors

Cited Authors

  • Raja, SM; Sanders, DB; Juel, VC; Harati, Y; Smith, AG; Pascuzzi, R; Richman, DP; Wu, A; AleŇ°, KL; Jacobus, LR; Jacobus, DP; Guptill, JT; DAPPER Study Team,

Published Date

  • September 2019

Published In

Volume / Issue

  • 60 / 3

Start / End Page

  • 292 - 298

PubMed ID

  • 31269226

Pubmed Central ID

  • PMC7357813

Electronic International Standard Serial Number (EISSN)

  • 1097-4598

Digital Object Identifier (DOI)

  • 10.1002/mus.26625


  • eng

Conference Location

  • United States