Neonatal Therapeutics: Considerations for Dosing.

Published

Journal Article

Neonates are a uniquely vulnerable population, compromised by immature physiology and critical illness if born premature. Furthermore, neonates have frequent exposures to drugs that lack adequate data on safety, efficacy, and appropriate dosing in this population. Key physiologic differences between neonates and older children and adults affect drug absorption, distribution, metabolism, and elimination. Adequate understanding and consideration of these differences is essential to ensure optimal dosing of therapeutic agents in this vulnerable population. Moreover, direct study of neonates through appropriately designed pharmacokinetic and pharmacodynamic studies can ensure the development of safe and effective therapeutics in our youngest populations of patients.

Full Text

Duke Authors

Cited Authors

  • Zimmerman, KO; Benjamin, DK; Becker, ML

Published Date

  • July 2019

Published In

Volume / Issue

  • 36 / S 02

Start / End Page

  • S18 - S21

PubMed ID

  • 31238353

Pubmed Central ID

  • 31238353

Electronic International Standard Serial Number (EISSN)

  • 1098-8785

Digital Object Identifier (DOI)

  • 10.1055/s-0039-1691772

Language

  • eng

Conference Location

  • United States