Comparison of neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy for esophageal cancer: a meta-analysis.

Journal Article (Journal Article;Systematic Review)

Aim: To compare the clinical efficacy of neoadjuvant chemoradiotherapy (nCRT) and neoadjuvant chemotherapy (nCT) for esophageal cancer. Methods: Randomized controlled trials reporting on the comparison of nCRT and nCT for esophageal cancer were identified. Results: Three eligible randomized controlled trials were identified and included with a total of 375 patients (189 nCRT, 186 nCT). Outcomes showed that compared with nCT group, R0 resection and pathologic complete response (pCR) rates were significantly increased in nCRT group. However, no significant difference was seen in 3- and 5-year progression-free survival or 3- and 5-year overall survival. Conclusion: The addition of radiotherapy to neoadjuvant chemotherapy results in higher R0 resection rate and pCR rate, without significantly impacting survival.

Full Text

Duke Authors

Cited Authors

  • Jing, S-W; Qin, J-J; Liu, Q; Zhai, C; Wu, Y-J; Cheng, Y-J; Czito, BG; Wang, J

Published Date

  • July 2019

Published In

Volume / Issue

  • 15 / 20

Start / End Page

  • 2413 - 2422

PubMed ID

  • 31269806

Electronic International Standard Serial Number (EISSN)

  • 1744-8301

Digital Object Identifier (DOI)

  • 10.2217/fon-2019-0024

Language

  • eng

Conference Location

  • England