Skip to main content
Journal cover image

Comparison of neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy for esophageal cancer: a meta-analysis.

Publication ,  Journal Article
Jing, S-W; Qin, J-J; Liu, Q; Zhai, C; Wu, Y-J; Cheng, Y-J; Czito, BG; Wang, J
Published in: Future Oncol
July 2019

Aim: To compare the clinical efficacy of neoadjuvant chemoradiotherapy (nCRT) and neoadjuvant chemotherapy (nCT) for esophageal cancer. Methods: Randomized controlled trials reporting on the comparison of nCRT and nCT for esophageal cancer were identified. Results: Three eligible randomized controlled trials were identified and included with a total of 375 patients (189 nCRT, 186 nCT). Outcomes showed that compared with nCT group, R0 resection and pathologic complete response (pCR) rates were significantly increased in nCRT group. However, no significant difference was seen in 3- and 5-year progression-free survival or 3- and 5-year overall survival. Conclusion: The addition of radiotherapy to neoadjuvant chemotherapy results in higher R0 resection rate and pCR rate, without significantly impacting survival.

Duke Scholars

Published In

Future Oncol

DOI

EISSN

1744-8301

Publication Date

July 2019

Volume

15

Issue

20

Start / End Page

2413 / 2422

Location

England

Related Subject Headings

  • Survival Analysis
  • Randomized Controlled Trials as Topic
  • Progression-Free Survival
  • Oncology & Carcinogenesis
  • Neoadjuvant Therapy
  • Humans
  • Esophagectomy
  • Esophageal Neoplasms
  • Chemoradiotherapy
  • Antineoplastic Combined Chemotherapy Protocols
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Jing, S.-W., Qin, J.-J., Liu, Q., Zhai, C., Wu, Y.-J., Cheng, Y.-J., … Wang, J. (2019). Comparison of neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy for esophageal cancer: a meta-analysis. Future Oncol, 15(20), 2413–2422. https://doi.org/10.2217/fon-2019-0024
Jing, Shao-Wu, Jian-Jun Qin, Qing Liu, Chang Zhai, Ya-Jing Wu, Yun-Jie Cheng, Brian G. Czito, and Jun Wang. “Comparison of neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy for esophageal cancer: a meta-analysis.Future Oncol 15, no. 20 (July 2019): 2413–22. https://doi.org/10.2217/fon-2019-0024.
Jing S-W, Qin J-J, Liu Q, Zhai C, Wu Y-J, Cheng Y-J, et al. Comparison of neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy for esophageal cancer: a meta-analysis. Future Oncol. 2019 Jul;15(20):2413–22.
Jing, Shao-Wu, et al. “Comparison of neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy for esophageal cancer: a meta-analysis.Future Oncol, vol. 15, no. 20, July 2019, pp. 2413–22. Pubmed, doi:10.2217/fon-2019-0024.
Jing S-W, Qin J-J, Liu Q, Zhai C, Wu Y-J, Cheng Y-J, Czito BG, Wang J. Comparison of neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy for esophageal cancer: a meta-analysis. Future Oncol. 2019 Jul;15(20):2413–2422.
Journal cover image

Published In

Future Oncol

DOI

EISSN

1744-8301

Publication Date

July 2019

Volume

15

Issue

20

Start / End Page

2413 / 2422

Location

England

Related Subject Headings

  • Survival Analysis
  • Randomized Controlled Trials as Topic
  • Progression-Free Survival
  • Oncology & Carcinogenesis
  • Neoadjuvant Therapy
  • Humans
  • Esophagectomy
  • Esophageal Neoplasms
  • Chemoradiotherapy
  • Antineoplastic Combined Chemotherapy Protocols